PGS Publication: PGP000816

Publication Information (EuropePMC)
Title Genetic risk, adherence to healthy lifestyle behaviors, and risk of cholelithiasis: A population-based cohort study.
PubMed ID 38548025(Europe PMC)
doi 10.1016/j.ypmed.2024.107942
Publication Date March 27, 2024
Journal Prev Med
Author(s) Mi N, Liang Z, Yang M, Zhao J, Tian L, Huang C, Xie P, Wu S, He Q, Sun Y, Lin Y, Yue P, Xia B, Yuan J, Meng W.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012582
(PRS13_cholelithiasis)
 PGP000816 |
Mi N et al. Prev Med (2024)
 Cholelithiasis cholelithiasis 13
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012582/ScoringFiles/PGS012582.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030739 PGS012582
(PRS13_cholelithiasis)
 PSS012273|
European Ancestry|
317,640 individuals
 PGP000816 |
Mi N et al. Prev Med (2024)
 Reported Trait: cholelithiasis — — Hazard ratio (HR, high vs low tertile): 1.24 [1.16, 1.32] age, sex, UK Biobank assessment centers, and additionally adjusted for index of multiple deprivation, overall health rating, long-standing illness, obesity, dyslipidemia for triglycerides, dyslipidemia for high-density lipoprotein cholesterol, hypertension, hyperglycemia, multivitamin use, mineral use, aspirin use, non-steroidal anti-inflammatory drugs use, statin use, proton pump inhibitors use, lifestyle factors (diet, smoking, alcohol consumption, coffee consumption, physical activity and body weight) —
PPM030740 PGS012582
(PRS13_cholelithiasis)
 PSS012273|
European Ancestry|
317,640 individuals
 PGP000816 |
Mi N et al. Prev Med (2024)
 Reported Trait: cholelithiasis x lifestyle interaction — — Hazard ratio (HR, unfavorable lifestyle and high PRS vs. favorable lifestyle and low PRS): 1.98 [1.67, 2.35] cerides, dyslipidemia for high-density lipoprotein cholesterol, hypertension, hyperglycemia, multivitamin use, mineral use, aspirin use, non-steroidal anti-inflammatory drugs use, statin use and proton pump inhibitors use —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012273 — Median = 12.7 years
[
  • 11,017 cases
  • , 306,623 controls
]
,
48.1 % Male samples
 Mean = 56.7 years
Sd = 7.97 years		 European — UKB —