PGS Publication: PGP000818

Publication Information (EuropePMC)
Title Social isolation and the risk of Parkinson disease in the UK biobank study.
PubMed ID 38589402(Europe PMC)
doi 10.1038/s41531-024-00700-7
Publication Date April 8, 2024
Journal NPJ Parkinsons Dis
Author(s) Geng T, Li Y, Peng Y, Chen X, Xu X, Wang J, Sun L, Gao X.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012584
(PRS44_PD)
 PGP000818 |
Geng T et al. NPJ Parkinsons Dis (2024)
 Parkinson's disease Parkinson disease 44
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012584/ScoringFiles/PGS012584.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030743 PGS012584
(PRS44_PD)
 PSS012275|
Multi-ancestry (including European)|
192,340 individuals
 PGP000818 |
Geng T et al. NPJ Parkinsons Dis (2024)
 Reported Trait: Parkinson's disease HR: 1.07 [1.05, 1.08] — — age at recruitment (continuous, years), and sex (men, women) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012275 — — 186,624 individuals,
46.3 % Male samples
 Mean = 64.2 years
Sd = 2.9 years		 European — UKB —
PSS012275 — — 5,716 individuals,
46.3 % Male samples
 Mean = 64.2 years
Sd = 2.9 years		 Not reported — UKB —