PGS Publication: PGP000821

Publication Information (EuropePMC)
Title Investigating the Association of Polygenic Risk Scores With Thyroid Cancer Susceptibility in a Han Chinese Population.
PubMed ID 38550279(Europe PMC)
doi 10.1210/jendso/bvae052
Publication Date March 16, 2024
Journal J Endocr Soc
Author(s) Chen YH, Chen IC, Chou CM, Huang SY.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000797
(CC_Thyroid_IV)
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Thyroid cancer thyroid gland carcinoma 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000797/ScoringFiles/PGS000797.txt.gz
PGS000087
(CC_Thyroid)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Thyroid cancer thyroid gland carcinoma 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000087/ScoringFiles/PGS000087.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030751 PGS000797
(CC_Thyroid_IV)
 PSS012279|
East Asian Ancestry|
4,063 individuals
 PGP000821 |
Chen YH et al. J Endocr Soc (2024)
|Ext.		 Reported Trait: Thyroid cancer — — Hazard ratio (HR, high vs low tertile): 1.151 [1.053, 1.258] — —
PPM030752 PGS000087
(CC_Thyroid)
 PSS012279|
East Asian Ancestry|
4,063 individuals
 PGP000821 |
Chen YH et al. J Endocr Soc (2024)
|Ext.		 Reported Trait: Thyroid cancer — — Hazard ratio (HR, high vs low tertile): 1.147 [1.049, 1.254] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012279 — —
[
  • 839 cases
  • , 3,224 controls
]
 — East Asian
(Han Chinese)		 — TPMI —