PGS Publication: PGP000828

Publication Information (EuropePMC)
Title Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study.
PubMed ID 38403640(Europe PMC)
doi 10.5551/jat.64623
Publication Date Feb. 23, 2024
Journal J Atheroscler Thromb
Author(s) Kujala I, Vangipurapu J, Maaniitty T, Saraste A, Kere J, Knuuti J.
Released in PGS Catalog: July 15, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000329
(PRS_CHD)
 PGP000100 |
Mars N et al. Nat Med (2020)
 Coronary heart disease coronary artery disorder 6,423,165
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000329/ScoringFiles/PGS000329.txt.gz
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disorder 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disorder 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036556 PGS000329
(PRS_CHD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: Coronary atherosclerosis OR: 1.4 [1.21, 1.62] — — age, sex, hypertension, diabetes, smoking, dyslipidemia, family history of premature CAD and symptoms —
PPM036557 PGS000018
(metaGRS_CAD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: Coronary atherosclerosis OR: 1.62 [1.39, 1.89] — — age, sex, hypertension, diabetes, smoking, dyslipidemia, family history of premature CAD and symptoms —
PPM036558 PGS000013
(GPS_CAD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: Coronary atherosclerosis OR: 1.62 [1.39, 1.88] — — age, sex, hypertension, diabetes, smoking, dyslipidemia, family history of premature CAD and symptoms —
PPM036559 PGS000329
(PRS_CHD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: Obstructive CAD OR: 1.25 [1.07, 1.46] AUROC: 0.561 — age, sex, hypertension, diabetes, smoking, dyslipidemia, family history of premature CAD and symptoms —
PPM036560 PGS000018
(metaGRS_CAD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: Obstructive CAD OR: 1.68 [1.42, 1.97] AUROC: 0.63 — age, sex, hypertension, diabetes, smoking, dyslipidemia, family history of premature CAD and symptoms —
PPM036561 PGS000013
(GPS_CAD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: Obstructive CAD OR: 1.7 [1.44, 2.01] AUROC: 0.64 — age, sex, hypertension, diabetes, smoking, dyslipidemia, family history of premature CAD and symptoms —
PPM036562 PGS000329
(PRS_CHD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: coronary atherosclerosis OR: 1.25 [1.07, 1.46] AUROC: 0.589 — — —
PPM036563 PGS000018
(metaGRS_CAD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: coronary atherosclerosis OR: 1.68 [1.42, 1.97] AUROC: 0.635 — — —
PPM036564 PGS000013
(GPS_CAD)
 PSS012311|
European Ancestry|
943 individuals
 PGP000828 |
Kujala I et al. J Atheroscler Thromb (2024)
|Ext.		 Reported Trait: coronary atherosclerosis OR: 1.7 [1.44, 2.01] AUROC: 0.63 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012311 — —
[
  • 670 cases
  • , 273 controls
]
,
40.3 % Male samples
 Mean = 64.0 years
Sd = 8.6 years		 European — NR —