PGS Publication: PGP000829

Publication Information (EuropePMC)
Title Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.
PubMed ID 38652672(Europe PMC)
doi 10.2337/dc23-2274
Publication Date June 1, 2024
Journal Diabetes Care
Author(s) Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, Vy HMT, Lin Z, Armstrong ND, Gu S, Tsao NL, Lange LA, Wang N, Wiggins KL, Trompet S, Liu S, Loos RJF, Judy R, Schroeder PH, Hasbani NR, Bos MM, Morrison AC, Jackson RD, Reiner AP, Manson JE, Chaudhary NS, Carmichael LK, Chen YI, Taylor KD, Ghanbari M, van Meurs J, Pitsillides AN, Psaty BM, Noordam R, Do R, Park KS, Jukema JW, Kavousi M, Correa A, Rich SS, Damrauer SM, Hajek C, Cho NH, Irvin MR, Pankow JS, Nadkarni GN, Sladek R, Goodarzi MO, Florez JC, Chasman DI, Heckbert SR, Kooperberg C, Dupuis J, Malhotra R, de Vries PS, Liu CT, Rotter JI, Meigs JB, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Released in PGS Catalog: July 15, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000058
(CAD_GRS_204)
 PGP000043 |
Morieri ML et al. Diabetes Care (2018)
 Coronary artery disease coronary artery disorder 204
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000058/ScoringFiles/PGS000058.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036565 PGS000058
(CAD_GRS_204)
 PSS012312|
Multi-ancestry (including European)|
49,230 individuals
 PGP000829 |
Kwak SH et al. Diabetes Care (2024)
|Ext.		 Reported Trait: Incident cardiovascular disease in type 2 diabetes HR: 1.14 [1.12, 1.16] — — age at diagnosis of T2D, sex, principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012312 — — 31,118 individuals — European — 14 cohorts
  • ARIC
  • ,BioMe
  • ,CHS
  • ,FHS
  • ,MESA
  • ,MGBB
  • ,PMB
  • ,PROSPER
  • ,REGARDS
  • ,RS
  • ,SANFORD
  • ,UKB
  • ,WGHS
  • ,WHI
 —
PSS012312 — — 11,124 individuals — African American or Afro-Caribbean — 8 cohorts
  • ARIC
  • ,BioMe
  • ,CHS
  • ,JHS
  • ,MESA
  • ,PMB
  • ,REGARDS
  • ,WHI
 —
PSS012312 — — 4,325 individuals — Hispanic or Latin American — BioMe, MESA, WHI —
PSS012312 — — 2,663 individuals — East Asian — KoGES, MESA, WHI —