| Publication Information (EuropePMC) | |
| Title | Excess Weight, Polygenic Risk Score, and Findings of Colorectal Neoplasms at Screening Colonoscopy. |
| PubMed ID | 38704818(Europe PMC) |
| doi | 10.14309/ajg.0000000000002853 |
| Publication Date | May 3, 2024 |
| Journal | Am J Gastroenterol |
| Author(s) | Fu R, Chen X, Niedermaier T, Seum T, Hoffmeister M, Brenner H. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002265 (PRS140_CRC) |
PGP000294 | Thomas M et al. Am J Hum Genet (2020) |
Colorectal cancer | colorectal cancer | 140 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002265/ScoringFiles/PGS002265.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM038145 | PGS002265 (PRS140_CRC) |
PSS013838| European Ancestry| 3,427 individuals |
PGP000843 | Fu R et al. Am J Gastroenterol (2024) |Ext. |
Reported Trait: Advanced colorectal neoplasm | OR: 1.56 [1.41, 1.73] | — | — | age, sex, education, smoking status, physical activity, alcohol consumption, red and processed meat consumption, history of hormone replacement therapy, history of diabetes, use of NSAIDs, family history of CRC in a first-degree relative, history of colonoscopy, BMI | — |
| PPM038146 | PGS002265 (PRS140_CRC) |
PSS013839| European Ancestry| 4,784 individuals |
PGP000843 | Fu R et al. Am J Gastroenterol (2024) |Ext. |
Reported Trait: Any colorectal neoplasm x BMI interaction | — | — | Odds ratio (OR >30 BMI and high PRS vs. <25 BMI and low PRS): 2.29 [1.72, 3.06] | age, sex, education, smoking status, physical activity, alcohol consumption, red and processed meat consumption, history of hormone replacement therapy, history of diabetes, use of NSAIDs, family history of CRC in a first-degree relative, and history of colonoscopy | — |
| PPM038147 | PGS002265 (PRS140_CRC) |
PSS013838| European Ancestry| 3,427 individuals |
PGP000843 | Fu R et al. Am J Gastroenterol (2024) |Ext. |
Reported Trait: Advanced colorectal neoplasm x BMI interaction | — | — | Odds ratio (OR >30 BMI and high PRS vs. <25 BMI and low PRS): 2.9 [1.93, 4.33] | age, sex, education, smoking status, physical activity, alcohol consumption, red and processed meat consumption, history of hormone replacement therapy, history of diabetes, use of NSAIDs, family history of CRC in a first-degree relative, and history of colonoscopy | — |
| PPM038144 | PGS002265 (PRS140_CRC) |
PSS013839| European Ancestry| 4,784 individuals |
PGP000843 | Fu R et al. Am J Gastroenterol (2024) |Ext. |
Reported Trait: Any colorectal neoplasm | OR: 1.39 [1.3, 1.5] | — | — | age, sex, education, smoking status, physical activity, alcohol consumption, red and processed meat consumption, history of hormone replacement therapy, history of diabetes, use of NSAIDs, family history of CRC in a first-degree relative, history of colonoscopy, BMI | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS013838 | — | — | [ ,
48.0 % Male samples |
— | European | — | BLITZ | — |
| PSS013839 | — | — | [ ,
32.0 % Male samples |
— | European | — | BLITZ | — |