PGS Publication: PGP000847

Publication Information (EuropePMC)
Title Developing a Polygenic Risk Score with Age and Sex to Identify High-Risk Myopia in Taiwan.
PubMed ID 39062192(Europe PMC)
doi 10.3390/biomedicines12071619
Publication Date July 20, 2024
Journal Biomedicines
Author(s) Lin HJ, Huang YT, Liao WL, Huang YC, Chang YW, Weng AL, Tsai FJ.
Released in PGS Catalog: Aug. 26, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019957
(prs149_myopia)
 PGP000847 |
Lin HJ et al. Biomedicines (2024)
 Myopia Myopia 149
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019957/ScoringFiles/PGS019957.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038153 PGS019957
(prs149_myopia)
 PSS013845|
East Asian Ancestry|
4,352 individuals
 PGP000847 |
Lin HJ et al. Biomedicines (2024)
 Reported Trait: High myopia (aged >18 years) — AUROC: 0.8 [0.78, 0.81] Odds ratio (OR, high vs low tertile): 1.3 [1.09, 1.55] age, sex —
PPM038154 PGS019957
(prs149_myopia)
 PSS013849|
East Asian Ancestry|
7,192 individuals
 PGP000847 |
Lin HJ et al. Biomedicines (2024)
 Reported Trait: Moderate myopia (aged >18 years) — AUROC: 0.78 [0.77, 0.8] Odds ratio (OR, high vs low tertile): 1.23 [1.09, 1.39] age, sex —
PPM038155 PGS019957
(prs149_myopia)
 PSS013848|
East Asian Ancestry|
5,504 individuals
 PGP000847 |
Lin HJ et al. Biomedicines (2024)
 Reported Trait: Mild myopia (aged >18 years) — AUROC: 0.73 [0.72, 0.75] — age, sex —
PPM038156 PGS019957
(prs149_myopia)
 PSS013846|
East Asian Ancestry|
2,060 individuals
 PGP000847 |
Lin HJ et al. Biomedicines (2024)
 Reported Trait: High myopia (aged 7-18 years) — AUROC: 0.703 [0.66, 0.75] — age, sex —
PPM038157 PGS019957
(prs149_myopia)
 PSS013847|
East Asian Ancestry|
950 individuals
 PGP000847 |
Lin HJ et al. Biomedicines (2024)
 Reported Trait: High myopia (aged <6 years) — AUROC: 0.65 [0.61, 0.69] Odds ratio (OR, high vs low tertile): 1.17 [1.02, 1.34] age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013845 — —
[
  • 1,089 cases
  • , 3,263 controls
]
 — East Asian
(Han Chinese)		 — NR —
PSS013846 — —
[
  • 262 cases
  • , 1,798 controls
]
 — East Asian
(Han Chinese)		 — NR —
PSS013847 — —
[
  • 360 cases
  • , 590 controls
]
 — East Asian
(Han Chinese)		 — NR —
PSS013848 — —
[
  • 2,241 cases
  • , 3,263 controls
]
 — East Asian
(Han Chinese)		 — NR —
PSS013849 — —
[
  • 3,929 cases
  • , 3,263 controls
]
 — East Asian
(Han Chinese)		 — NR —