Polygenic Score (PGS) ID: PGS000013

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Oct. 14, 2019
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Terms and Licenses
Freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering (partnering@broadinstitute.org).

Score Details

Score Construction
PGS Name GPS_CAD
Development Method
Name LDpred
Parameters ρ = 0.001; LD panel = 503 1000G Europeans
Variants
Original Genome Build hg19
Number of Variants 6,630,150
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000006
Citation (link to publication) Khera AV et al. Nat Genet (2018)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 75.3%
South Asian: 13.6%
East Asian: 6%
Hispanic or Latin American: 2.2%
African: 1.7%
Greater Middle Eastern: 1.2%
187,599 individuals (100%)
Score Development/Training
European: 100%
120,280 individuals (100%)
PGS Evaluation
European: 49.2%
Multi-ancestry (including European): 15.9%
  • European
  • Hispanic or Latin American
  • African
  • East Asian
  • South Asian
  • Not Reported
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
African: 9.5%
Hispanic or Latin American: 9.5%
South Asian: 6.3%
East Asian: 4.8%
Not Reported: 3.2%
Additional Asian Ancestries: 1.6%
63 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST003116
Europe PMC: 26343387
11,323 individuals East Asian 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
25,557 individuals South Asian 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
4,095 individuals Hispanic or Latin American 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
141,217 individuals European 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
3,139 individuals African American or Afro-Caribbean 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
2,268 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) 40 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
[
  • 3,963 cases
  • , 116,317 controls
]
European UKB CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). UKB Phase 1

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001620 PSS000837|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.7 [0.677, 0.721] Δ C-index (PRS+covariates vs. covariates alone): -0.001 [-0.009, 0.006] Pooled cohort risk percentile, age, sex, PCs (1-5)
PPM001011 PSS000515|
African Ancestry|
6,979 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.58 PCs (1-10) of ancestry
PPM001010 PSS000517|
Hispanic or Latin American Ancestry|
7,048 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.63 PCs (1-10) of ancestry
PPM001009 PSS000516|
European Ancestry|
10,344 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.53 PCs (1-10) of ancestry
PPM001008 PSS000515|
African Ancestry|
6,979 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.29 [1.23, 1.34] age, sex, PCs (1-10) of ancestry
PPM001007 PSS000517|
Hispanic or Latin American Ancestry|
7,048 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.5 [1.44, 1.57] age, sex, PCs (1-10) of ancestry
PPM001006 PSS000516|
European Ancestry|
10,344 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.52 [1.46, 1.58] age, sex, PCs (1-10) of ancestry
PPM001005 PSS000514|
Multi-ancestry (including European)|
24,371 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.61 PCs (1-10) of ancestry
PPM001004 PSS000519|
Multi-ancestry (including European)|
9,070 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.6 PCs (1-10) of ancestry
PPM001003 PSS000518|
Multi-ancestry (including European)|
13,667 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.59 PCs (1-10) of ancestry
PPM001002 PSS000514|
Multi-ancestry (including European)|
24,371 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.35, 1.48] age, sex, PCs (1-10) of ancestry
PPM001001 PSS000519|
Multi-ancestry (including European)|
9,070 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.45 [1.38, 1.52] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000383 PSS000219|
European Ancestry|
11,010 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Coronary artery disease (personal history) OR: 1.589 [1.32, 1.92] AUROC: 0.86 age, sex
PPM001000 PSS000518|
Multi-ancestry (including European)|
13,667 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.41 [1.34, 1.47] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000999 PSS000520|
Multi-ancestry (including European)|
47,108 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.38, 1.46] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000402 PSS000227|
Additional Asian Ancestries|
544 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.16 [1.35, 1.59] Odds Ratio (OR; top 5% vs. rest): 3.33 [0.82, 13.51] 4 genetic PCs
PPM000596 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.16 [0.96, 1.41] C-index: 0.659 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000593 PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.19 [1.07, 1.33] C-index: 0.656 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000619 PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.17 [1.04, 1.31] C-index: 0.712 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000615 PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.47 [1.41, 1.54] C-index: 0.75 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000623 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.39] C-index: 0.708 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000590 PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.5 [1.43, 1.56] C-index: 0.719 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000022 PSS000015|
European Ancestry|
288,978 individuals
PGP000006 |
Khera AV et al. Nat Genet (2018)
Reported Trait: Coronary artery disease AUROC: 0.81 [0.81, 0.81] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.04 age; sex; Ancestry PC 1-4; genotyping chip
PPM000030 PSS000021|
European Ancestry|
1,964 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.64 [1.48, 1.81] AUROC: 0.72 [0.7, 0.74] age, sex, first four genetic PCs
PPM000031 PSS000022|
European Ancestry|
3,309 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.55 [1.38, 1.73] AUROC: 0.89 [0.88, 0.91] age, sex, first four genetic PCs
PPM000032 PSS000019|
European Ancestry|
5,762 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.69 [1.44, 1.99] AUROC: 0.84 [0.81, 0.87] age, sex, first four genetic PCs, cohort recruitment centre
PPM000033 PSS000020|
European Ancestry|
3,195 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Reccurent coronary artery disease events OR: 1.13 [1.06, 1.22] age, sex, first four genetic PCs
PPM000401 PSS000229|
Hispanic or Latin American Ancestry|
919 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.56 [1.29, 1.88] Odds Ratio (OR; top 5% vs. rest): 3.38 [2.03, 5.64] 4 genetic PCs
PPM000400 PSS000228|
African Ancestry|
1,298 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.46 [1.28, 1.66] Odds Ratio (OR; top 5% vs. rest): 2.02 [1.29, 3.16] 4 genetic PCs
PPM000399 PSS000230|
European Ancestry|
3,081 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.06 [1.89, 2.25] Odds Ratio (OR; top 5% vs. rest): 5.09 [3.82, 6.78] 4 genetic PCs
PPM000387 PSS000219|
European Ancestry|
11,010 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Coronary artery disease (personal history) AUROC: 0.6
PPM000933 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.768 [0.76, 0.776] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000932 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.756 [0.75, 0.762] age, sex, PCs (1-10)
PPM000929 PSS000468|
Multi-ancestry (including European)|
5,685 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.802 [0.763, 0.8841] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000928 PSS000468|
Multi-ancestry (including European)|
5,685 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.759 [0.724, 0.794] age, sex, PCs (1-10)
PPM000927 PSS000468|
Multi-ancestry (including European)|
5,685 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.45 [1.34, 1.56] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM000930 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.53 [1.49, 1.56] age, sex
PPM000926 PSS000467|
Multi-ancestry (including European)|
28,556 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.45 [1.4, 1.49] age, sex
PPM000931 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.46 [1.42, 1.49] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM002182 PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
|Ext.
Reported Trait: Incident coronary heart disease C-index: 0.573 [0.5254, 0.6212] Only 6,481,934 SNPs from PGS000013 were utilised. SNPs were not included due to imputation quality R^2 < 0.3
PPM000605 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.42 [1.25, 1.61] AUROC: 0.776 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000602 PSS000331|
African Ancestry|
7,597 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.3 [1.21, 1.41] AUROC: 0.771 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000599 PSS000333|
European Ancestry|
45,645 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.66 [1.62, 1.71] AUROC: 0.77 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM001746 PSS000898|
African Ancestry|
16,755 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.25 [1.12, 1.4] PCs(1-4)
PPM001747 PSS000902|
South Asian Ancestry|
8,102 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.47 [1.36, 1.59] PCs(1-4)
PPM001749 PSS000901|
Hispanic or Latin American Ancestry|
9,085 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.52 [1.43, 1.62] PCs(1-4)
PPM000747 PSS000367|
South Asian Ancestry|
7,244 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.5302 AUROC: 0.8021 age, sex, top 5 genetic PCs
PPM000748 PSS000365|
South Asian Ancestry|
491 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Myocardial infarction (first-ever) OR: 1.4605 AUROC: 0.6482 age, sex, top 5 genetic PCs
PPM000749 PSS000366|
South Asian Ancestry|
2,963 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.5793 AUROC: 0.7066 age, sex, top 5 genetic PCs
PPM001617 PSS000839|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Prevalent and incident coronary heart disease OR: 1.89 [1.75, 2.03] Age, sex, PCs (1-5)
PPM001618 PSS000837|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.24 [1.15, 1.34] C-index: 0.669 [0.644, 0.691] Age, sex, PCs (1-5)
PPM001619 PSS000838|
European Ancestry|
2,390 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.38 [1.21, 1.58] C-index: 0.672 [0.627, 0.705] Age, sex, PCs (1-5)
PPM001621 PSS000838|
European Ancestry|
2,390 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.681 [0.637, 0.715] Δ C-index (PRS+covariates vs. covariates alone): 0.021 [-0.0004, 0.043] Pooled cohort risk percentile, age, sex, PCs (1-5)
PPM001622 PSS000837|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.549 [0.521, 0.571] PCs (1-5)
PPM001623 PSS000838|
European Ancestry|
2,390 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.587 [0.532, 0.623] PCs (1-5)
PPM001745 PSS000900|
European Ancestry|
474,498 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.6 [1.44, 1.78] PCs(1-4)
PPM001748 PSS000899|
East Asian Ancestry|
3,988 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.66 [1.47, 1.86] PCs(1-4)
PPM001848 PSS000929|
European Ancestry|
5,581 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.6699 [0.6557, 0.684]
PPM001849 PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.5617 [0.5402, 0.5833]
PPM001850 PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.6374 [0.6335, 0.6412] May be an overlap between score development and testing samples
PPM002183 PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
|Ext.
Reported Trait: Incident coronary heart disease C-index: 0.7752 [0.7443, 0.8029] Age, sex, survey Only 6,481,934 SNPs from PGS000013 were utilised. SNPs were not included due to imputation quality R^2 < 0.3
PPM002184 PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
|Ext.
Reported Trait: Incident coronary heart disease C-index: 0.8012 [0.7775, 0.8353] Age, sex, survey, Framingham risk score (diabetes status, current and former smoking status, systolic blood pressure, antihypertensive medication, HDL cholesterol, total cholesterol) Only 6,481,934 SNPs from PGS000013 were utilised. SNPs were not included due to imputation quality R^2 < 0.3
PPM009241 PSS007665|
European Ancestry|
1,132 individuals
PGP000257 |
Wells QS et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Coronary artery calcium score > 20 OR: 1.74 [1.29, 2.36] AUROC: 0.794 [0.728, 0.84] Age, sex, PCs(1-5)
PPM009242 PSS007665|
European Ancestry|
1,132 individuals
PGP000257 |
Wells QS et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Coronary artery calcium score > 20 OR: 1.87 [1.41, 2.5]
PPM009243 PSS007665|
European Ancestry|
1,132 individuals
PGP000257 |
Wells QS et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Coronary artery calcium score > 20 AUROC: 0.864 [0.807, 0.904] C statistic change (vs. no PRS): 0.015 [0.004, 0.028]
Integrated discrimination improvement (vs. no PRS): 0.027 [-0.006, 0.054]
Age, sex, PCs(1-5), systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, triglycerides, current smoker, waist circumference
PPM009244 PSS007666|
European Ancestry|
663 individuals
PGP000257 |
Wells QS et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Coronary artery calcium score > 300 OR: 1.9 [1.42, 2.54] AUROC: 0.804 [0.751, 0.845] Age, sex, PCs(1-5)
PPM009245 PSS007666|
European Ancestry|
663 individuals
PGP000257 |
Wells QS et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Coronary artery calcium score > 300 OR: 2.11 [1.57, 2.83]
PPM009246 PSS007666|
European Ancestry|
663 individuals
PGP000257 |
Wells QS et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Coronary artery calcium score > 300 AUROC: 0.855 [0.805, 0.887] C statistic change (vs. no PRS): 0.02 [0.001, 0.039]
Integrated discrimination improvement (vs. no PRS): 0.039 [0.0005, 0.072]
Age, sex, PCs(1-5), systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, triglycerides, current smoker, body mass index
PPM012880 PSS009590|
Multi-ancestry (including European)|
5,152 individuals
PGP000290 |
Mordi IR et al. Diabetes Care (2022)
|Ext.
Reported Trait: Incident major adverse cardiovascular events in type 2 diabetes HR: 1.68 [1.49, 1.9] Age, sex, glycated hemoglobin, duration of diabetes, retinal risk score, and PCE
PPM012881 PSS009590|
Multi-ancestry (including European)|
5,152 individuals
PGP000290 |
Mordi IR et al. Diabetes Care (2022)
|Ext.
Reported Trait: Incident major adverse cardiovascular events in type 2 diabetes AUROC: 0.686 [0.667, 0.704] Retinal risk score, age, sex
PPM017189 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Acute myocardial infarction or revascularization OR: 1.52 [1.45, 1.59] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017190 PSS010160|
African Ancestry|
76,709 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Acute myocardial infarction or revascularization OR: 1.17 [1.14, 1.21] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017191 PSS010162|
European Ancestry|
292,438 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Coronary artery disease OR: 1.36 [1.35, 1.37] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017192 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Coronary artery disease OR: 1.32 [1.28, 1.36] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017193 PSS010160|
African Ancestry|
76,709 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Coronary artery disease OR: 1.1 [1.08, 1.12] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017194 PSS010162|
European Ancestry|
292,438 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.46 [1.43, 1.49] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017196 PSS010160|
African Ancestry|
76,709 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.15 [1.1, 1.2] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017197 PSS010162|
European Ancestry|
292,438 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Incident coronary artery disease OR: 1.26 [1.24, 1.28] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017198 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Incident coronary artery disease OR: 1.22 [1.15, 1.29] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017199 PSS010160|
African Ancestry|
76,709 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Incident coronary artery disease OR: 1.1 [1.07, 1.14] age, sex, genotyping batch and top 10 genotype-based PCs
PPM014904 PSS009922|
European Ancestry|
2,119 individuals
PGP000353 |
Sapkota Y et al. JACC CardioOncol (2022)
|Ext.
Reported Trait: Coronary artery disease in childhood cancer survivors HR: 1.25 [1.04, 1.49]
PPM014905 PSS009922|
European Ancestry|
2,119 individuals
PGP000353 |
Sapkota Y et al. JACC CardioOncol (2022)
|Ext.
Reported Trait: Coronary artery disease in childhood cancer survivors aged <10 years at diagnosis and treated with >25 Gy AUROC: 0.714 Hazard Ratio (HR, top vs. bottom tertile): 15.49 [5.24, 45.52]
PPM015491 PSS009960|
Ancestry Not Reported|
172,066 individuals
PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.
Reported Trait: 10-year risk of coronary artery disease for slow walkers Hazard Ratio (HR, top 20% vs. bottom 80%): 9.6 [8.62, 10.57]
PPM015493 PSS009960|
Ancestry Not Reported|
172,066 individuals
PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.
Reported Trait: Difference in 10-year risk of coronary artery disease between slow walkers and brisk walkers Hazard Ratio (HR, top 20% vs. bottom 80%): 3.63 [2.58, 4.67]
PPM015521 PSS009971|
Multi-ancestry (including European)|
36,422 individuals
PGP000381 |
Hao L et al. Nat Med (2022)
|Ext.
Reported Trait: Coronary artery disease OR: 1.86 [1.69, 2.05] 4 genetic PCs
PPM015490 PSS009961|
Ancestry Not Reported|
208,627 individuals
PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.
Reported Trait: 10-year risk of coronary artery disease for slow walkers Hazard Ratio (HR, top 20% vs. bottom 80%): 2.72 [2.3, 3.13]
PPM015492 PSS009961|
Ancestry Not Reported|
208,627 individuals
PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.
Reported Trait: Difference in 10-year risk of coronary artery disease between slow walkers and brisk walkers Hazard Ratio (HR, top 20% vs. bottom 80%): 1.26 [0.81, 1.71]
PPM015494 PSS009961|
Ancestry Not Reported|
208,627 individuals
PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.
Reported Trait: 10-year risk of coronary artery disease C-index: 0.801 [0.793, 0.808] Age (continuous), Townsend deprivation index (continuous), systolic blood pressure (continuous), LDL cholesterol (continuous), smoking status (current/former/never), history of diabetes (yes/no), family history of myocardial infarction (yes/no), walking pace
PPM015495 PSS009960|
Ancestry Not Reported|
172,066 individuals
PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.
Reported Trait: 10-year risk of coronary artery disease C-index: 0.732 [0.728, 0.737] Age (continuous), Townsend deprivation index (continuous), systolic blood pressure (continuous), LDL cholesterol (continuous), smoking status (current/former/never), history of diabetes (yes/no), family history of myocardial infarction (yes/no), walking pace
PPM017088 PSS010120|
European Ancestry|
4,218 individuals
PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.
Reported Trait: Atherosclerotic cardiovascular disease (incident and prevalent) OR: 1.34 [1.2, 1.5] AUROC: 0.766 [0.741, 0.792] sex, age
PPM017089 PSS010122|
European Ancestry|
4,218 individuals
PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.6 [1.44, 1.79] AUROC: 0.784 [0.76, 0.808] sex, age
PPM017090 PSS010119|
European Ancestry|
3,383 individuals
PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.
Reported Trait: Incident atherosclerotic cardiovascular disease HR: 1.29 [1.13, 1.48] sex, age, 10 principal components
PPM017091 PSS010121|
European Ancestry|
3,383 individuals
PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.59 [1.41, 1.8] sex, age, 10 principal components
PPM017188 PSS010162|
European Ancestry|
292,438 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Acute myocardial infarction or revascularization OR: 1.51 [1.49, 1.53] age, sex, genotyping batch and top 10 genotype-based PCs
PPM017195 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.
Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.49 [1.38, 1.61] age, sex, genotyping batch and top 10 genotype-based PCs
PPM020267 PSS011315|
East Asian Ancestry|
901 individuals
PGP000534 |
Bhak Y et al. PLoS One (2021)
|Ext.
Reported Trait: Early onset acute myocardial infarction following percutaneous coronary intervention OR: 1.83 [1.69, 1.99] AUROC: 0.65 [0.61, 0.69]
PPM020269 PSS011316|
East Asian Ancestry|
197 individuals
PGP000534 |
Bhak Y et al. PLoS One (2021)
|Ext.
Reported Trait: Cumulative event of repeat revascularization following percutaneous coronary intervention HR: 1.64 [1.12, 2.38] Hazard ratio (HR, top 50% vs bottom 50%): 2.19 [1.47, 2.36]
PPM020270 PSS011316|
East Asian Ancestry|
197 individuals
PGP000534 |
Bhak Y et al. PLoS One (2021)
|Ext.
Reported Trait: Cumulative event of repeat revascularization following percutaneous coronary intervention HR: 1.65 [1.11, 2.46] Body mass index, hypertension, current smoking, diabetes mellitus, hypercholesterolemia, family history of coronary artery disease
PPM020268 PSS011315|
East Asian Ancestry|
901 individuals
PGP000534 |
Bhak Y et al. PLoS One (2021)
|Ext.
Reported Trait: Early onset acute myocardial infarction following percutaneous coronary intervention AUROC: 0.92 [0.9, 0.94] Current smoking, hypercholesterolemia, body mass index, hypertension, family history of coronary artery disease, diabetes mellitus significant contribution of the PRS to the risk factor model p=0.015
PPM020713 PSS011380|
European Ancestry|
1,863 individuals
PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.
Reported Trait: Incident coronary heart diseaase HR: 1.82 [1.56, 2.12] 30-year traditional risk factor score linear predictor
PPM020714 PSS011379|
European Ancestry|
2,154 individuals
PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.
Reported Trait: Incident coronary heart diseaase HR: 1.6 [1.43, 1.79] 30-year traditional risk factor score linear predictor
PPM020715 PSS011378|
European Ancestry|
5,740 individuals
PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.
Reported Trait: Incident coronary heart diseaase HR: 1.16 [1.09, 1.23] 30-year traditional risk factor score linear predictor
PPM020716 PSS011380|
European Ancestry|
1,863 individuals
PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.
Reported Trait: Incident coronary heart diseaase HR: 1.98 [1.7, 2.3] C-index: 0.73 Age, sex
PPM020717 PSS011379|
European Ancestry|
2,154 individuals
PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.
Reported Trait: Incident coronary heart diseaase HR: 1.64 [1.47, 1.84] C-index: 0.66 Age, sex
PPM020718 PSS011378|
European Ancestry|
5,740 individuals
PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.
Reported Trait: Incident coronary heart diseaase HR: 1.22 [1.15, 1.3] C-index: 0.66 Age, sex
PPM021296 PSS011679|
Multi-ancestry (including European)|
90,053 individuals
PGP000626 |
Douville NJ et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Myocardial injury following non cardiac surgery OR: 1.23 [1.11, 1.37] AUROC: 0.72 (0.011) Age, sex, race
PPM021297 PSS011679|
Multi-ancestry (including European)|
90,053 individuals
PGP000626 |
Douville NJ et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Myocardial injury following non cardiac surgery OR: 1.12 [1.02, 1.24] AUROC: 0.793 (0.014) High-risk surgery, history of ischemic heart disease, history of congestive heart failure, history of cerebrovascular disease, insulin therapy for diabetes mellitus, preoperative creatinine >2.0 mg/dL
PPM021298 PSS011679|
Multi-ancestry (including European)|
90,053 individuals
PGP000626 |
Douville NJ et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Myocardial injury following non cardiac surgery OR: 1.19 [1.07, 1.31] AUROC: 0.912 (0.006) Age, admission type (admit and inpatient versus outpatient reference), composite RCRI score, history of a cardiac arrhythmia, history of fluid or electrolyte disorder, history of hypertension
PPM021299 PSS011679|
Multi-ancestry (including European)|
90,053 individuals
PGP000626 |
Douville NJ et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Myocardial injury following non cardiac surgery OR: 1.17 [1.06, 1.3] AUROC: 0.921 (0.006) Age, admission type (admit and inpatient versus outpatient reference), composite RCRI score, history of a cardiac arrhythmia, history of fluid or electrolyte disorder, history of hypertension, case duration (hours), pRBC transfusion (units), crystalloid resuscitation (L), estimated blood loss (L), total epinephrine dose (100mcg), total ephedrine dose (50mcg), total norepinephrine dose (40mcg), total phenylephrine dose (1000mcg), total vasopressin dose (10 units), time with myocardial injury after non cardiac surgery < 50 mmHg (min).
PPM021334 PSS011689|
European Ancestry|
5,453 individuals
PGP000632 |
Aday AW et al. Atherosclerosis (2023)
|Ext.
Reported Trait: Incident myocardial infarction or fatal coronary event HR: 1.37 [1.26, 1.49] C-index: 0.74 [0.71, 0.76] Age, sex, 5 PCs, pooled cohort equations, high-sensitivity C-reactive protein
PPM021333 PSS011690|
European Ancestry|
2,017 individuals
PGP000632 |
Aday AW et al. Atherosclerosis (2023)
|Ext.
Reported Trait: Incident myocardial infarction or fatal coronary event HR: 1.38 [1.16, 1.63] C-index: 0.74 [0.69, 0.77] Age, sex, 5 PCs, pooled cohort equations, high-sensitivity C-reactive protein

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000365 Case-control study of first-onset acute myocardial infarction 244 individuals,
90.2 % Male samples
Mean = 33.0 years
IQR = [30.0, 35.0] years
South Asian BRAVE
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease.
[
  • 1,800 cases
]
,
90.2 % Male samples
Mean = 54.0 years
IQR = [46.0, 60.0] years
South Asian MedGenome
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease. 1,163 individuals,
76.4 % Male samples
Mean = 55.0 years
IQR = [49.0, 62.0] years
South Asian MedGenome
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 398 cases
]
,
86.7 % Male samples
Mean = 60.6 years
IQR = [54.4, 66.1] years
South Asian UKB
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). 6,846 individuals,
52.1 % Male samples
Mean = 52.8 years
IQR = [46.3, 60.2] years
South Asian UKB
PSS011689 Mean = 14.2 years
[
  • 565 cases
  • , 4,888 controls
]
,
42.3 % Male samples
Mean = 63.0 years
Sd = 5.7 years
European ARIC
PSS011690 Mean = 18.5 years
[
  • 153 cases
  • , 1,864 controls
]
,
44.2 % Male samples
Mean = 56.7 years
Sd = 9.2 years
European FOS
PSS000898 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,370 cases
  • , 15,385 controls
]
African unspecified BioMe, MESA, PHB, UKB, VIRGO
PSS000899 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 435 cases
  • , 3,553 controls
]
East Asian TaiChi, UKB
PSS000900 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 26,462 cases
  • , 448,036 controls
]
European BioMe, MESA, PHB, UKB, VIRGO
PSS000901 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,224 cases
  • , 7,861 controls
]
Hispanic or Latin American BioMe, MESA, PHB, VIRGO
PSS000902 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 874 cases
  • , 7,228 controls
]
South Asian BRAVE, UKB
PSS009922
[
  • 120 cases
  • , 1,999 controls
]
European NR
PSS009960 172,066 individuals,
100.0 % Male samples
Mean = 57.8 years Not reported UKB
PSS009961 208,627 individuals,
0.0 % Male samples
Mean = 57.4 years Not reported UKB
PSS000837 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Median = 15.5 years
[
  • 696 cases
  • , 4,151 controls
]
,
43.6 % Male samples
Mean = 62.9 years European ARIC
PSS000838 Incident CHD cases were defined as MI, resuscitated cardiac arrest, definite or probable angina if followed by a revascularization, and CHD dead occuring by visit 5. Median = 14.2 years
[
  • 227 cases
  • , 2,163 controls
]
,
47.8 % Male samples
Mean = 61.8 years European MESA
PSS000839 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Prevalent CHD cases were participants with a reported history of MI, heart or arterial surgery, coronary artery bypass graft surgery, or angioplasty; or evidence of having had an MI based on electrocardiogram taken at their visit 1 examination.
[
  • 1,005 cases
  • , 3,842 controls
]
,
43.6 % Male samples
Mean = 62.9 years European ARIC
PSS000467 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. Median = 21.3 years
IQR = [16.1, 23.1] years
[
  • 4,122 cases
  • , 24,434 controls
]
,
38.7 % Male samples
Mean = 57.9 years European, NR European=28286, NR=270 MDC
PSS000468 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. All individuals included had measured cholesterol concentrations. Median = 23.2 years
IQR = [17.6, 24.2] years
[
  • 815 cases
  • , 4,870 controls
]
,
41.16 % Male samples
European, NR European=5640, NR=45 MDC-CC Cardiovascular Cohort
PSS000469 Individuals were free of CAD at time of enrollment. CAD was defined based on hospitalisation with or death due to ICD-10 codes for acute or subsequent myocaridal infarction (I21, I22, I23, I24.1, and I25.2); or hospitalisation with ICD-9 codes for myocaridal. infarction (410, 411, and 412); or hospitalisation with OPCS-4 (Office of Population Censuses and Surveys) codes. for coronary artery bypass grafting (K40, K41, and K45) or coronary angioplasty with or without stenting (K49, K50.2, and K75). Median = 8.1 years
IQR = [7.4, 8.8] years
[
  • 7,708 cases
  • , 317,295 controls
]
,
44.2 % Male samples
Mean = 56.8 years European, African unspecified, South Asian, East Asian, NR European=304270, African unspecified=5760, South Asian=6832, East Asian (Chinese)=1117, NR=7024 UKB
PSS010120 Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, death of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.6, 14.6] years
[
  • 363 cases
  • , 3,855 controls
]
,
47.0 % Male samples
Mean = 53.4 years European CoLaus right censored was death or latest evidence of good health
PSS010122 Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from coronary heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.6, 14.6] years
[
  • 388 cases
  • , 3,830 controls
]
,
47.0 % Male samples
Mean = 53.4 years European CoLaus right censored was death or latest evidence of good health
PSS000514 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 2,824 cases
  • , 21,547 controls
]
,
42.7 % Male samples
Mean = 57.0 years European, Hispanic or Latin American, African unspecified African unspecified=6979, European=10344, Hispanic or Latin American=7048 BioMe
PSS000515 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 6,979 individuals African unspecified BioMe
PSS000516 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 10,344 individuals European BioMe
PSS000517 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 7,048 individuals Hispanic or Latin American BioMe
PSS000518 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 3,538 cases
  • , 10,129 controls
]
,
45.0 % Male samples
Mean = 60.0 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=867, East Asian=167, European=11725, Hispanic or Latin American=799, South Asian=109 PHB
PSS000519 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 4,658 cases
  • , 4,412 controls
]
,
59.0 % Male samples
Mean = 68.0 years European, African unspecified African unspecified=1927, European=7143 PMB
PSS000520 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 11,020 cases
  • , 36,088 controls
]
,
46.52 % Male samples
Mean = 59.6 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=9773, East Asian=167, European=29212, Hispanic or Latin America=7847, South Asian=109 BioMe, PHB, PMB
PSS010119 Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, death of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.7, 14.6] years
[
  • 190 cases
  • , 3,193 controls
]
,
45.0 % Male samples
Mean = 52.3 years European CoLaus right censored was death or latest evidence of good health, participant with statine therapy at baseline were excluded
PSS009590 individuals with type 2 diabetes. Events consist of 794 CV deaths (15.4%), 274 non-fatal MI (5.3%) and 151 non-fatal stroke (2.9%) Median = 9.8 years
[
  • 1,017 cases
  • , 4,135 controls
]
,
56.1 % Male samples
Mean = 65.2 years European, NR GoDARTS
PSS009971 30,716 individuals European MGBB
PSS000219 Phenotypic information was self-reported by the individual through an online, interactive health history tool
[
  • 126 cases
  • , 10,884 controls
]
,
17.1 % Male samples
European CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS009971 1,807 individuals African unspecified
(Black)
MGBB
PSS009971 786 individuals Asian unspecified MGBB
PSS009971 3,113 individuals Other MGBB
PSS010121 Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from coronary heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.7, 14.6] years
[
  • 195 cases
  • , 3,188 controls
]
,
45.0 % Male samples
Mean = 52.3 years European CoLaus right censored was death or latest evidence of good health, participant with statine therapy at baseline were excluded
PSS011380 1,863 individuals,
46.0 % Male samples
Median = 30.0 years
IQR = [26.0, 34.0] years
European FOS
PSS000227
[
  • 40 cases
  • , 504 controls
]
Asian unspecified MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000228
[
  • 336 cases
  • , 962 controls
]
African American or Afro-Caribbean MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000229
[
  • 168 cases
  • , 751 controls
]
Hispanic or Latin American MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000230
[
  • 1,537 cases
  • , 1,544 controls
]
European MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000015 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 8,676 cases
  • , 280,302 controls
]
European UKB UKB Phase 2
PSS007665 Of the 1,132 individuals, 1,070 had a coronary artery calcium (CAC) score ≤ 20, whilst the remaining 62 had a CAC score >20. To calculate CAC scores, participants underwent two computed tomography scans from the root of the aorta to the apex of the heart at year 15. From these, Agatston scores, adjusted using a standard calcium phantom scanned underneath each participant, were computed for the four major arteries. The CAC Agatston score is the average of two scans.
[
  • 62 cases
  • , 1,070 controls
]
,
48.1 % Male samples
Mean = 25.6 years
Sd = 3.3 years
European CARDIA
PSS007666 Of the 663 individuals, 500 individuals had a coronary artery calcium (CAC) score ≤ 300, whilst the remaining 93 had a CAC score > 300. To calculate CAC scores, participants underwent two computed tomography scans from the root of the aorta to the apex of the heart at year 30. From these, Agatston scores, adjusted using a standard calcium phantom scanned underneath each participant, were computed for the four major arteries. The CAC Agatston score is the average of two scans.
[
  • 93 cases
  • , 570 controls
]
,
46.5 % Male samples
Mean = 27.8 years
Sd = 4.7 years
European FOS
PSS000019 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 173 cases
  • , 5,589 controls
]
,
41.29 % Male samples
European
(French Canadian)
CARTaGENE
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 446 cases
  • , 416 controls
]
European
(French Canadian)
MHI Phase 1
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 937 cases
  • , 1,396 controls
]
European
(French Canadian)
MHI Phase 2
PSS000021 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 974 cases
  • , 976 controls
]
,
72.7 % Male samples
European
(French Canadian)
MHI Phase 1
PSS000022 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 2,492 cases
  • , 817 controls
]
,
72.38 % Male samples
European
(French Canadian)
MHI Phase 2
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
IQR = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
IQR = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
IQR = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
IQR = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
IQR = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
IQR = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS010160
[
  • 17,202 cases
  • , 59,507 controls
]
African American or Afro-Caribbean MVP
PSS010161
[
  • 6,378 cases
  • , 24,270 controls
]
Hispanic or Latin American MVP
PSS010162
[
  • 95,151 cases
  • , 197,287 controls
]
European MVP
PSS001063 Cases were individuals with incident coronary heart disesase (CHD). The outcome CHD was a combined endpoint of nonfatal myocardial infarction as well as coronary death and sudden death (International Classification of Disease 9th Revision: 410–414 and 798). Until December 2000, the diagnosis of a major, nonfatal myocardial infarction and coronary death was based on the MONICA algorithm in which a diagnosis of a major CHD event was based on symptoms, cardiac enzymes (creatine kinase, aspartate aminotransferase, and lactate dehydrogenase), serial changes from 12‐lead electrocardiograms (ECGs) evaluated by Minnesota coding, necropsy results and history of CHD in fatal cases. Since January 1, 2001, the diagnosis of myocardial infarction was based on the European Society of Cardiology and American College of Cardiology criteria. Incident events were identified through follow‐up questionnaires or through the MONICA/KORA myocardial infarction registry, which monitors the occurrence of all in‐ and out of‐hospital fatal and nonfatal myocardial infarctions among the 25–74‐year‐old inhabitants of the study region. Initially identified self‐reported incident cases and the self‐reported date of diagnosis not covered by the MONICA/KORA myocardial infarction registry, were validated by hospital records or by contacting the patient's treating physician. Deaths from myocardial in- farction were validated by death certificates, autopsy reports, chart reviews, or information from the last treating physician. Median = 14.0 years
IQR = [14.0, 14.0] years
[
  • 160 cases
  • , 2,749 controls
]
,
48.1 % Male samples
European KORA
PSS011315 The patients were hospitalized with a diagnosis of and treatment for an ST-segment elevation myocardial infarction or non-ST-segment elevation myocardial infarction; they were ≤50 years old and had undergone PCI at three hospitals. Median = 43.0 months
[
  • 265 cases
  • , 636 controls
]
,
63.82 % Male samples
East Asian
(Korean)
KGP
PSS011316 Cases were individuals with repeat revascularizations. The patients were hospitalized with a diagnosis of and treatment for an ST-segment elevation myocardial infarction or non-ST-segment elevation myocardial infarction; they were ≤50 years old and had undergone PCI at three hospitals.
[
  • 30 cases
  • , 167 controls
]
East Asian
(Korean)
KGP
PSS011679 Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation.
[
  • 3 cases
  • , 301 controls
]
Native American MGI
PSS011679 Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation.
[
  • 15 cases
  • , 3,134 controls
]
Not reported MGI
PSS011679 Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation.
[
  • 382 cases
  • , 80,483 controls
]
European MGI
PSS000929 For GERMIFSI and GERMIFSII, CAD was defined as Myocardinal infarction before the age of 60 and 1 or more 1st- degree relative with CAD. In GERMIFSIII CAD was defined as myocardial infarction between the ages of 26 and 74. In GERMIFSIV, cases were based on a CAD diagnosis before age 65 in men or age 70 in women. In Luric, cases were ascertained as >50% angiographic confirmation of vascular obstruction in 1 or more coronary vessel
[
  • 2,919 cases
  • , 2,662 controls
]
European GerMIFS, LURIC
PSS000930 CAD ascertainment was based on myocardial infarction diagnosis or death cause using ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2
[
  • 840 cases
  • , 26,208 controls
]
European EB
PSS000931 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on ICD-9 codes 410.X, 411.X, 412.X, or 429.79, or ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2. Coronary revascularization was assessed based on OPCS-4 coded procedure for coronary artery bypass grafting (K40.1-40-4, K41.1-41.4, or K45.1-45.5), or coronary angioplasty with or without stenting (K49.1-49.2, K49.0-49.9, K50.2, K75.1-75.4, or K75.8-75.9)
[
  • 21,025 cases
  • , 410,789 controls
]
European UKB
PSS011679 Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation.
[
  • 25 cases
  • , 4,589 controls
]
African unspecified MGI
PSS011679 Cases were individuals who had experienced mycoardial injury after non-cardiac surgery (MINS). MINS was defined as a new troponin elevation (≥ 0.1 ng/mL, institutional laboratory's upper threshold for normal) occurring within the first 30 days after surgery. If a patient underwent a subsequent surgery within the 30-day postoperative window, the later procedure was presumed to have greater influence on the subsequent postoperative course, therefore, the post-operative window for the initial procedure was censored at the start of a subsequent procedure. Patients with a troponin elevation in the two years before surgery were excluded from analysis for that particular surgery. If a patient had a postoperative troponin elevation, all subsequent surgeries were excluded from evaluation.
[
  • 4 cases
  • , 1,117 controls
]
Asian unspecified, Oceanian MGI
PSS011378 5,740 individuals,
46.0 % Male samples
Median = 52.0 years
IQR = [48.0, 56.0] years
European ARIC
PSS011379 2,154 individuals,
45.0 % Male samples
Median = 43.0 years
IQR = [41.0, 45.0] years
European FOS
PSS000365 Case-control study of first-onset acute myocardial infarction
[
  • 247 cases
]
,
90.7 % Male samples
Mean = 34.0 years
IQR = [30.0, 35.0] years
South Asian BRAVE