Polygenic Score (PGS) ID: PGS000697

Predicted Trait
Reported Trait Total bilirubin [umol/L]
Mapped Trait(s) bilirubin measurement (EFO_0004570)
Released in PGS Catalog: Feb. 3, 2021
Download Score FTP directory
Terms and Licenses
Creative Commons Attribution 4.0 International (CC BY 4.0)

Score Details

Score Construction
PGS Name snpnet.Total_bilirubin
Variants
Original Genome Build hg19
Number of Variants 1,159
Development Method
Name snpnet
Parameters 1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs)
PGS Source
PGS Catalog Publication (PGP) ID PGP000128
Citation (link to publication) Sinnott-Armstrong N et al. Nat Genet (2021)
Ancestry Distribution
Score Development/Training
European: 100%
255,256 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
223,327 individuals European
(British)
UKB Training
31,929 individuals European
(British)
UKB Validation

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001425 PSS000762|
African Ancestry|
5,978 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.38749
Spearman's ρ: 0.551
Age, sex, PCs(1-40)
PPM001565 PSS000766|
European Ancestry|
63,531 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.44377
Spearman's ρ: 0.533
Age, sex, PCs(1-40)
PPM001530 PSS000765|
South Asian Ancestry|
7,313 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.43693
Spearman's ρ: 0.548
Age, sex, PCs(1-40)
PPM001495 PSS000764|
European Ancestry|
23,472 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.42641
Spearman's ρ: 0.523
Age, sex, PCs(1-40)
PPM001460 PSS000763|
East Asian Ancestry|
1,069 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.2156
Spearman's ρ: 0.347
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000762 5,978 individuals African unspecified UKB
PSS000763 1,069 individuals East Asian UKB
PSS000764 23,472 individuals European Non-British White UKB
PSS000765 7,313 individuals South Asian UKB
PSS000766 63,531 individuals European
(British)
UKB