Polygenic Score (PGS) ID: PGS000727

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: Feb. 23, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name AF_PGS
Development Method
Name LD thinning
Parameters UKB was used for thinning (bi-allelic SNPs, MAF > 1%, INFO > 0.4, excluding palindromic SNPs); r2 threshold = 0.9
Variants
Original Genome Build GRCh37
Number of Variants 2,210,336
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000137
Citation (link to publication) Ritchie SC et al. Nat Metab (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
European: 50%
Multi-ancestry (excluding European): 50%
  • Greater Middle Eastern
  • South Asian
  • African
  • Not Reported
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European 6 cohorts
  • AFGen
  • ,HUNT
  • ,MGI
  • ,MyCode
  • ,UKB
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001668 PSS000867|
European Ancestry|
3,087 individuals
 PGP000137 |
Ritchie SC et al. Nat Metab (2021)
 Reported Trait: Incident atrial fibrillation HR: 1.72 [1.2, 2.47] — — age, sex, 10 genetic PCs —
PPM022657 PSS012048|
Multi-ancestry (excluding European)|
14,259 individuals
 PGP000737 |
Qafoud F et al. J Clin Med (2024)
|Ext.		 Reported Trait: Atrial fibrillation OR: 1.43 [1.03, 1.97] AUROC: 0.55 — sex, age, and 5 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012048 — — 655 individuals — African unspecified — NR —
PSS012048 — — 6,816 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Arabs)		 — QBB —
PSS012048 — — 2,620 individuals — South Asian — NR —
PSS000867 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I48 Median = 6.9 years
[
  • 33 cases
  • , 3,054 controls
]
,
51.0 % Male samples
 Median = 44.0 years
IQR = [30.5, 54.7] years		 European — INTERVAL —
PSS012048 — — 4,168 individuals — Not reported — NR —