| Publication Information (EuropePMC) | |
| Title | Genetic Susceptibility to Arrhythmia Phenotypes in a Middle Eastern Cohort of 14,259 Whole-Genome Sequenced Individuals. |
| PubMed ID | 38398418(Europe PMC) |
| doi | 10.3390/jcm13041102 |
| Publication Date | Feb. 15, 2024 |
| Journal | J Clin Med |
| Author(s) | Qafoud F, Elshrif M, Kunji K, Althani A, Salam A, Al Suwaidi J, Asaad N, Darbar D, Saad M. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000035 (PRS_AF) |
PGP000022 | Weng LC et al. Circulation (2017) |
Atrial fibrillation | atrial fibrillation | 1,168 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000035/ScoringFiles/PGS000035.txt.gz | |
| PGS000331 (PRS_AF) |
PGP000100 | Mars N et al. Nat Med (2020) |
Atrial fibrillation | atrial fibrillation | 6,183,494 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000331/ScoringFiles/PGS000331.txt.gz | |
| PGS000727 (AF_PGS) |
PGP000137 | Ritchie SC et al. Nat Metab (2021) |
Atrial fibrillation | atrial fibrillation | 2,210,336 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000727/ScoringFiles/PGS000727.txt.gz |
| PGS001339 (GBE_HC964) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Atrial fibrillation and flutter (time-to-event) | atrial fibrillation, atrial flutter |
2,142 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001339/ScoringFiles/PGS001339.txt.gz |
| PGS001340 (GBE_HC281) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Atrial fibrillation | atrial fibrillation | 2,955 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001340/ScoringFiles/PGS001340.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM022655 | PGS000035 (PRS_AF) |
PSS012048| Multi-ancestry (excluding European)| 14,259 individuals |
PGP000737 | Qafoud F et al. J Clin Med (2024) |Ext. |
Reported Trait: Atrial fibrillation | OR: 1.29 [1.02, 1.65] | AUROC: 0.58 | — | sex, age, and 5 PCs | — |
| PPM022656 | PGS000331 (PRS_AF) |
PSS012048| Multi-ancestry (excluding European)| 14,259 individuals |
PGP000737 | Qafoud F et al. J Clin Med (2024) |Ext. |
Reported Trait: Atrial fibrillation | OR: 1.33 [1.02, 1.73] | AUROC: 0.56 | — | sex, age, and 5 PCs | — |
| PPM022657 | PGS000727 (AF_PGS) |
PSS012048| Multi-ancestry (excluding European)| 14,259 individuals |
PGP000737 | Qafoud F et al. J Clin Med (2024) |Ext. |
Reported Trait: Atrial fibrillation | OR: 1.43 [1.03, 1.97] | AUROC: 0.55 | — | sex, age, and 5 PCs | — |
| PPM022658 | PGS001339 (GBE_HC964) |
PSS012048| Multi-ancestry (excluding European)| 14,259 individuals |
PGP000737 | Qafoud F et al. J Clin Med (2024) |Ext. |
Reported Trait: Atrial fibrillation | OR: 1.32 [1.04, 1.68] | AUROC: 0.56 | — | sex, age, and 5 PCs | — |
| PPM022659 | PGS001340 (GBE_HC281) |
PSS012048| Multi-ancestry (excluding European)| 14,259 individuals |
PGP000737 | Qafoud F et al. J Clin Med (2024) |Ext. |
Reported Trait: Atrial fibrillation | OR: 1.31 [1.02, 1.67] | AUROC: 0.56 | — | sex, age, and 5 PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012048 | — | — | 6,816 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) (Arabs) |
— | QBB | — |
| PSS012048 | — | — | 2,620 individuals | — | South Asian | — | NR | — |
| PSS012048 | — | — | 655 individuals | — | African unspecified | — | NR | — |
| PSS012048 | — | — | 4,168 individuals | — | Not reported | — | NR | — |