Polygenic Score (PGS) ID: PGS000767

Predicted Trait
Reported Trait Depression
Mapped Trait(s)
Additional Trait Information Collective score of three well-validated depression-related phenotypes: subjective well-being, depressive symptoms, neuroticism
Released in PGS Catalog: May 28, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS14
Development Method
Name Genome-wide significant variants
Parameters Top associations p<1e-4, INFO>0.8
Variants
Original Genome Build NR
Number of Variants 14
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000174
Citation (link to publication) Guffanti G et al. Transl Psychiatry (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
650,197 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Hispanic or Latin American
  • African
  • Additional Asian Ancestries
  • Not Reported
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST003766
Europe PMC: 27089181
 298,420 individuals European 43 cohorts
  • 23andMe
  • ,AEGS1
  • ,AGES
  • ,ALSPAC
  • ,ARIC
  • ,ASPS
  • ,B58C
  • ,BASE
  • ,BLSA
  • ,CROATIA-KORCULA
  • ,CROATIA-SPLIT
  • ,CoLaus
  • ,DHS
  • ,EGCUT
  • ,ELSA
  • ,ERF
  • ,FTC
  • ,GOYA
  • ,HBCS
  • ,HCS
  • ,HNR
  • ,HPFS
  • ,HRS
  • ,KORA
  • ,LBC
  • ,LifeLines
  • ,MCTFR
  • ,MESA
  • ,NEO
  • ,NFBC
  • ,NHS
  • ,NTR
  • ,QIMR
  • ,RS
  • ,RUSHMAP
  • ,STR
  • ,SardiNIA
  • ,TEDS
  • ,TRAILS
  • ,TwinsUK
  • ,UKB
  • ,YFS
  • ,deCODE
GWAS Catalog: GCST003769
Europe PMC: 27089181
 180,866 individuals European GERA, PGC, UKB
GWAS Catalog: GCST003770
Europe PMC: 27089181
 170,911 individuals European GPC, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001972 PSS000984|
Multi-ancestry (including European)|
62 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change — — R²: 0.065 PCs(1-2) —
PPM001973 PSS000985|
Multi-ancestry (including European)|
63 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen stress induced reward prediciton error change — — R²: 0.074 PCs(1-2) —
PPM001974 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral nucleus acumbens volume — — R²: 0.064 PCs(1-2) —
PPM001975 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen volume — — R²: 0.095 PCs(1-2) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000986 — — 73 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000984 — — 62 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000985 — — 63 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —