Trait: depressive symptom measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007006
Description quantification of the existence and severity of depressive symptoms, usually via a questionnaire such as the Center for Epidemiological Studies Depression Scale (CES-D)
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000144
(SelfRepDep)
 PGP000068 |
Cai N et al. Nat Genet (2020)
 Self-reported depression or depression symptoms depressive symptom measurement,
self-reported trait		 21,828
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000144/ScoringFiles/PGS000144.txt.gz
PGS000767
(GRS14)
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Depression depressive symptom measurement,
major depressive disorder		 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000767/ScoringFiles/PGS000767.txt.gz
PGS001898
(portability-PLR_depressed_for_1w)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Ever depressed for a whole week depressive symptom measurement 5,777
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001898/ScoringFiles/PGS001898.txt.gz
PGS001899
(portability-PLR_depression_feelings)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Recent feelings of depression depressive symptom measurement 2,434
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001899/ScoringFiles/PGS001899.txt.gz
PGS002111
(portability-ldpred2_depressed_for_1w)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Ever depressed for a whole week depressive symptom measurement 791,873
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002111/ScoringFiles/PGS002111.txt.gz
PGS002112
(portability-ldpred2_depression_feelings)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Recent feelings of depression depressive symptom measurement 748,601
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002112/ScoringFiles/PGS002112.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000436 PGS000144
(SelfRepDep)
 PSS000250|
European Ancestry|
36,709 individuals
 PGP000068 |
Cai N et al. Nat Genet (2020)
 Reported Trait: Major Depressive Disorder status — AUROC: 0.51641 R²: 0.00117 Cohort —
PPM038419 PGS000144
(SelfRepDep)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.04621 — — — —
PPM001972 PGS000767
(GRS14)
 PSS000984|
Multi-ancestry (including European)|
62 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change — — R²: 0.065 PCs(1-2) —
PPM001973 PGS000767
(GRS14)
 PSS000985|
Multi-ancestry (including European)|
63 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen stress induced reward prediciton error change — — R²: 0.074 PCs(1-2) —
PPM001974 PGS000767
(GRS14)
 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral nucleus acumbens volume — — R²: 0.064 PCs(1-2) —
PPM001975 PGS000767
(GRS14)
 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen volume — — R²: 0.095 PCs(1-2) —
PPM010067 PGS001898
(portability-PLR_depressed_for_1w)
 PSS009394|
European Ancestry|
6,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0769 [0.0526, 0.1012] sex, age, birth date, deprivation index, 16 PCs —
PPM010068 PGS001898
(portability-PLR_depressed_for_1w)
 PSS009168|
European Ancestry|
1,519 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0019 [-0.0525, 0.0488] sex, age, birth date, deprivation index, 16 PCs —
PPM010069 PGS001898
(portability-PLR_depressed_for_1w)
 PSS008722|
European Ancestry|
2,506 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0432 [0.0039, 0.0824] sex, age, birth date, deprivation index, 16 PCs —
PPM010070 PGS001898
(portability-PLR_depressed_for_1w)
 PSS008496|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0058 [-0.0833, 0.0947] sex, age, birth date, deprivation index, 16 PCs —
PPM010072 PGS001898
(portability-PLR_depressed_for_1w)
 PSS008051|
East Asian Ancestry|
751 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.028 [-0.1003, 0.0446] sex, age, birth date, deprivation index, 16 PCs —
PPM010073 PGS001898
(portability-PLR_depressed_for_1w)
 PSS007838|
African Ancestry|
1,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0344 [-0.0173, 0.086] sex, age, birth date, deprivation index, 16 PCs —
PPM010074 PGS001898
(portability-PLR_depressed_for_1w)
 PSS008942|
African Ancestry|
2,067 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.031 [-0.0742, 0.0123] sex, age, birth date, deprivation index, 16 PCs —
PPM010071 PGS001898
(portability-PLR_depressed_for_1w)
 PSS008274|
South Asian Ancestry|
3,525 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.026 [-0.0071, 0.0591] sex, age, birth date, deprivation index, 16 PCs —
PPM038461 PGS001898
(portability-PLR_depressed_for_1w)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.03757 — — — —
PPM010075 PGS001899
(portability-PLR_depression_feelings)
 PSS009395|
European Ancestry|
6,438 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0302 [0.0058, 0.0546] sex, age, birth date, deprivation index, 16 PCs —
PPM010076 PGS001899
(portability-PLR_depression_feelings)
 PSS009169|
European Ancestry|
1,240 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): -0.006 [-0.0621, 0.0502] sex, age, birth date, deprivation index, 16 PCs —
PPM010077 PGS001899
(portability-PLR_depression_feelings)
 PSS008723|
European Ancestry|
2,249 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0308 [-0.0107, 0.0723] sex, age, birth date, deprivation index, 16 PCs —
PPM010078 PGS001899
(portability-PLR_depression_feelings)
 PSS008497|
Greater Middle Eastern Ancestry|
201 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0872 [-0.0594, 0.2301] sex, age, birth date, deprivation index, 16 PCs —
PPM010079 PGS001899
(portability-PLR_depression_feelings)
 PSS008275|
South Asian Ancestry|
813 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0462 [-0.0235, 0.1155] sex, age, birth date, deprivation index, 16 PCs —
PPM010080 PGS001899
(portability-PLR_depression_feelings)
 PSS008052|
East Asian Ancestry|
424 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0145 [-0.0832, 0.1119] sex, age, birth date, deprivation index, 16 PCs —
PPM010081 PGS001899
(portability-PLR_depression_feelings)
 PSS007839|
African Ancestry|
371 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): -0.0165 [-0.121, 0.0883] sex, age, birth date, deprivation index, 16 PCs —
PPM010082 PGS001899
(portability-PLR_depression_feelings)
 PSS008943|
African Ancestry|
510 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0197 [-0.069, 0.1081] sex, age, birth date, deprivation index, 16 PCs —
PPM030667 PGS001899
(portability-PLR_depression_feelings)
 PSS012230|
Greater Middle Eastern Ancestry|
1,359 individuals
 PGP000795 |
Smeeth D et al. Dev Psychopathol (2023)
|Ext.		 Reported Trait: Resilience (late-mid puberty) OR: 1.00e-08 [0.0, 0.07] — — age, gender,10 genetic principal components —
PPM038636 PGS001899
(portability-PLR_depression_feelings)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.02421 — — — —
PPM011743 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS009394|
European Ancestry|
6,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.1053 [0.0811, 0.1295] sex, age, birth date, deprivation index, 16 PCs —
PPM011744 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS009168|
European Ancestry|
1,519 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0816 [0.0311, 0.1317] sex, age, birth date, deprivation index, 16 PCs —
PPM011745 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS008722|
European Ancestry|
2,506 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0665 [0.0273, 0.1055] sex, age, birth date, deprivation index, 16 PCs —
PPM011746 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS008496|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0079 [-0.0968, 0.0812] sex, age, birth date, deprivation index, 16 PCs —
PPM011747 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS008274|
South Asian Ancestry|
3,525 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0554 [0.0223, 0.0883] sex, age, birth date, deprivation index, 16 PCs —
PPM011748 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS008051|
East Asian Ancestry|
751 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0086 [-0.0811, 0.064] sex, age, birth date, deprivation index, 16 PCs —
PPM011749 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS007838|
African Ancestry|
1,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0277 [-0.0241, 0.0793] sex, age, birth date, deprivation index, 16 PCs —
PPM011750 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS008942|
African Ancestry|
2,067 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0201 [-0.0633, 0.0233] sex, age, birth date, deprivation index, 16 PCs —
PPM038344 PGS002111
(portability-ldpred2_depressed_for_1w)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.06934 — — — —
PPM011753 PGS002112
(portability-ldpred2_depression_feelings)
 PSS008723|
European Ancestry|
2,249 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0477 [0.0062, 0.089] sex, age, birth date, deprivation index, 16 PCs —
PPM011751 PGS002112
(portability-ldpred2_depression_feelings)
 PSS009395|
European Ancestry|
6,438 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0692 [0.0448, 0.0935] sex, age, birth date, deprivation index, 16 PCs —
PPM011752 PGS002112
(portability-ldpred2_depression_feelings)
 PSS009169|
European Ancestry|
1,240 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0846 [0.0286, 0.1401] sex, age, birth date, deprivation index, 16 PCs —
PPM011754 PGS002112
(portability-ldpred2_depression_feelings)
 PSS008497|
Greater Middle Eastern Ancestry|
201 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.1366 [-0.0094, 0.277] sex, age, birth date, deprivation index, 16 PCs —
PPM011755 PGS002112
(portability-ldpred2_depression_feelings)
 PSS008275|
South Asian Ancestry|
813 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0591 [-0.0105, 0.1282] sex, age, birth date, deprivation index, 16 PCs —
PPM011756 PGS002112
(portability-ldpred2_depression_feelings)
 PSS008052|
East Asian Ancestry|
424 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): -0.0078 [-0.1053, 0.0898] sex, age, birth date, deprivation index, 16 PCs —
PPM011757 PGS002112
(portability-ldpred2_depression_feelings)
 PSS007839|
African Ancestry|
371 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): -0.0278 [-0.1321, 0.0771] sex, age, birth date, deprivation index, 16 PCs —
PPM011758 PGS002112
(portability-ldpred2_depression_feelings)
 PSS008943|
African Ancestry|
510 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of depression — — Partial Correlation (partial-r): 0.0623 [-0.0264, 0.1501] sex, age, birth date, deprivation index, 16 PCs —
PPM038376 PGS002112
(portability-ldpred2_depression_feelings)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.05836 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009168 — — 1,519 individuals — European Poland (NE Europe) UKB —
PSS009169 — — 1,240 individuals — European Poland (NE Europe) UKB —
PSS008274 — — 3,525 individuals — South Asian India (South Asia) UKB —
PSS008275 — — 813 individuals — South Asian India (South Asia) UKB —
PSS012230 — — 1,359 individuals,
47.24 % Male samples
 Mean = 11.23 years
Sd = 2.39 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Syrian)		 — BIOPATH —
PSS008942 — — 2,067 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008943 — — 510 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008051 — — 751 individuals — East Asian China (East Asia) UKB —
PSS008052 — — 424 individuals — East Asian China (East Asia) UKB —
PSS008722 — — 2,506 individuals — European Italy (South Europe) UKB —
PSS008723 — — 2,249 individuals — European Italy (South Europe) UKB —
PSS007838 — — 1,457 individuals — African American or Afro-Caribbean Carribean UKB —
PSS007839 — — 371 individuals — African American or Afro-Caribbean Carribean UKB —
PSS000984 — — 62 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000985 — — 63 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000986 — — 73 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS008496 — — 505 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008497 — — 201 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009394 — — 6,445 individuals — European UK (+ Ireland) UKB —
PSS009395 — — 6,438 individuals — European UK (+ Ireland) UKB —
PSS000250 — —
[
  • 14,696 cases
  • , 22,013 controls
]
 — European — 15 cohorts
  • BOMA
  • ,CoLaus
  • ,Edinburgh
  • ,GenPOD
  • ,GenRED
  • ,MARS
  • ,MPIP
  • ,NESDA
  • ,QIMR
  • ,RADIANT
  • ,RS
  • ,SHIP
  • ,STAR*D
  • ,TwinGene
  • ,i2b2
 Part of PGC29 (PMID: 29700475)
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —