Polygenic Score (PGS) ID: PGS000835

Predicted Trait
Reported Trait Insulin secretion rate
Mapped Trait(s) insulin secretion trait (OBA_VT0003564)
Released in PGS Catalog: Nov. 4, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name ISR
Development Method
Name Genome-wide significant variants
Parameters r2=0.5, 250kb window
Variants
Original Genome Build GRCh37
Number of Variants 319
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000211
Citation (link to publication) Aly DM et al. Nat Genet (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Hispanic or Latin American: 48.4%
European: 44.7%
Additional Diverse Ancestries: 6.9%
4,828 individuals (100%)
PGS Evaluation
European: 71.4%
South Asian: 28.6%
7 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004487
Europe PMC: 28490609
 2,337 individuals Hispanic or Latin American NR
GWAS Catalog: GCST004487
Europe PMC: 28490609
 2,159 individuals European NR
GWAS Catalog: GCST004487
Europe PMC: 28490609
 332 individuals Native American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002258 PSS001086|
European Ancestry|
3,194 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Severe Autoimmune Diabetes OR: 1.06 [0.96, 1.17] — — PC1-10 —
PPM002259 PSS001087|
European Ancestry|
3,930 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Severe Insulin-Deficient Diabetes OR: 0.84 [0.78, 0.9] — — PC1-10 —
PPM002260 PSS001088|
European Ancestry|
3,869 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Severe Insulin-Resistant Diabetes OR: 1.02 [0.95, 1.1] — — PC1-10 —
PPM002261 PSS001085|
European Ancestry|
4,116 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Moderate Obesity-related Diabetes OR: 0.89 [0.83, 0.95] — — PC1-10 —
PPM002262 PSS001084|
European Ancestry|
5,597 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Moderate Age-Related Diabetes OR: 0.88 [0.83, 0.92] — — PC1-10 —
PPM020178 PSS011301|
South Asian Ancestry|
1,282 individuals
 PGP000525 |
Yajnik CS et al. Lancet Reg Health Southeast Asia (2023)
|Ext.		 Reported Trait: Type 2 diabetes OR: 0.72 [0.6, 0.85] — — age, sex and BMI —
PPM020191 PSS011302|
South Asian Ancestry|
830 individuals
 PGP000525 |
Yajnik CS et al. Lancet Reg Health Southeast Asia (2023)
|Ext.		 Reported Trait: Severe insulin deficiency diabetes OR: 0.86 [0.74, 0.99] — — sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011301 — —
[
  • 821 cases
  • , 461 controls
]
 — South Asian
(Indian)		 — WellGen —
PSS011302 — —
[
  • 369 cases
  • , 461 controls
]
 — South Asian
(Indian)		 — WellGen —
PSS001084 Moderate Age-Related Diabetes (MARD) vs. controls —
[
  • 2,853 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001085 Moderate Obesity-related Diabetes (MOD) vs. controls —
[
  • 1,372 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001086 Severe Autoimmune Diabetes (SAID) vs. controls —
[
  • 450 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001087 Severe Insulin-Deficient Diabetes (SIDD) vs. controls —
[
  • 1,186 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001088 Severe Insulin-Resistant Diabetes (SIRD) vs. controls —
[
  • 1,125 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —