Polygenic Score (PGS) ID: PGS000998

Predicted Trait
Reported Trait Comparative body height at age 10
Mapped Trait(s) comparative body size at age 10, self-reported (EFO_0009819)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/QT_FC1001697
Released in PGS Catalog: Oct. 21, 2021
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Score Details

Score Construction
PGS Name GBE_QT_FC1001697
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 24,144
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
265,710 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 265,710 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007753 PSS007576|
African Ancestry|
6,049 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Comparative height size at age 10 — — R²: 0.02069 [0.01384, 0.02754]
Incremental R2 (full-covars): 0.01167
PGS R2 (no covariates): 0.0149 [0.00905, 0.02074]		 age, sex, UKB array type, Genotype PCs —
PPM007754 PSS007577|
East Asian Ancestry|
1,574 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Comparative height size at age 10 — — R²: 0.05189 [0.03143, 0.07236]
Incremental R2 (full-covars): 0.02937
PGS R2 (no covariates): 0.03568 [0.01842, 0.05294]		 age, sex, UKB array type, Genotype PCs —
PPM007755 PSS007578|
European Ancestry|
24,391 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Comparative height size at age 10 — — R²: 0.1366 [0.12868, 0.14453]
Incremental R2 (full-covars): 0.12631
PGS R2 (no covariates): 0.13848 [0.13052, 0.14644]		 age, sex, UKB array type, Genotype PCs —
PPM007756 PSS007579|
South Asian Ancestry|
7,225 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Comparative height size at age 10 — — R²: 0.05926 [0.04912, 0.0694]
Incremental R2 (full-covars): 0.05228
PGS R2 (no covariates): 0.05606 [0.04617, 0.06596]		 age, sex, UKB array type, Genotype PCs —
PPM007757 PSS007580|
European Ancestry|
66,430 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Comparative height size at age 10 — — R²: 0.1468 [0.14186, 0.15173]
Incremental R2 (full-covars): 0.14445
PGS R2 (no covariates): 0.14612 [0.1412, 0.15105]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007580 — — 66,430 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007576 — — 6,049 individuals — African unspecified — UKB —
PSS007577 — — 1,574 individuals — East Asian — UKB —
PSS007578 — — 24,391 individuals — European non-white British ancestry UKB —
PSS007579 — — 7,225 individuals — South Asian — UKB —