Trait: comparative body size at age 10, self-reported

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009819
Description Description of an individual's body size at age 10 compared to average, as reported by the individual.
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000716
(PGS295_elbs)
PGP000132 |
Richardson TG et al. BMJ (2020)
Early life body size body mass index,
comparative body size at age 10, self-reported
295
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000716/ScoringFiles/PGS000716.txt.gz
PGS000998
(GBE_QT_FC1001697)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Comparative body height at age 10 comparative body size at age 10, self-reported 24,144
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000998/ScoringFiles/PGS000998.txt.gz
PGS000999
(GBE_QT_FC1001687)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Comparative body size at age 10 comparative body size at age 10, self-reported 13,034
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000999/ScoringFiles/PGS000999.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001708 PGS000716
(PGS295_elbs)
PSS000883|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 30-69.9 AUROC: 0.569 [0.564, 0.574] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001709 PGS000716
(PGS295_elbs)
PSS000876|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 12-15.9 AUROC: 0.656 [0.626, 0.686] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001710 PGS000716
(PGS295_elbs)
PSS000878|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 16-17.9 AUROC: 0.623 [0.589, 0.657] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001711 PGS000716
(PGS295_elbs)
PSS000880|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 18-23.9 AUROC: 0.601 [0.589, 0.612] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001712 PGS000716
(PGS295_elbs)
PSS000882|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 14-29.9 AUROC: 0.591 [0.582, 0.6] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001713 PGS000716
(PGS295_elbs)
PSS000884|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 30-69.9 AUROC: 0.568 [0.563, 0.573] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001707 PGS000716
(PGS295_elbs)
PSS000879|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 18-23.9 AUROC: 0.618 [0.594, 0.641] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001687 PGS000716
(PGS295_elbs)
PSS000879|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 18-23.9 AUROC: 0.619 [0.596, 0.643] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001688 PGS000716
(PGS295_elbs)
PSS000881|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 24-29.9 AUROC: 0.602 [0.585, 0.618] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001689 PGS000716
(PGS295_elbs)
PSS000883|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 30-69.9 AUROC: 0.569 [0.564, 0.574] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001690 PGS000716
(PGS295_elbs)
PSS000876|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 12-15.9 AUROC: 0.658 [0.628, 0.687] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001691 PGS000716
(PGS295_elbs)
PSS000878|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 16-17.9 AUROC: 0.624 [0.589, 0.658] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001692 PGS000716
(PGS295_elbs)
PSS000880|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 18-23.9 AUROC: 0.602 [0.59, 0.613] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001693 PGS000716
(PGS295_elbs)
PSS000882|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 14-29.9 AUROC: 0.591 [0.582, 0.6] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001633 PGS000716
(PGS295_elbs)
PSS000849|
European Ancestry|
5,898 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Childhood body mass index AUROC: 0.64
PPM001635 PGS000716
(PGS295_elbs)
PSS000847|
European Ancestry|
3,997 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Adolescent body mass index AUROC: 0.63
PPM001637 PGS000716
(PGS295_elbs)
PSS000848|
European Ancestry|
2,199 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Adult body mass index AUROC: 0.57
PPM001705 PGS000716
(PGS295_elbs)
PSS000875|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 12-15.9 AUROC: 0.739 [0.667, 0.811] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001706 PGS000716
(PGS295_elbs)
PSS000877|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 16-17.9 AUROC: 0.66 [0.566, 0.754] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001685 PGS000716
(PGS295_elbs)
PSS000875|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 12-15.9 AUROC: 0.735 [0.663, 0.806] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001686 PGS000716
(PGS295_elbs)
PSS000877|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 16-17.9 AUROC: 0.672 [0.577, 0.766] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001694 PGS000716
(PGS295_elbs)
PSS000884|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 30-69.9 AUROC: 0.568 [0.563, 0.573] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM007753 PGS000998
(GBE_QT_FC1001697)
PSS007576|
African Ancestry|
6,049 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative height size at age 10 : 0.02069 [0.01384, 0.02754]
Incremental R2 (full-covars): 0.01167
PGS R2 (no covariates): 0.0149 [0.00905, 0.02074]
age, sex, UKB array type, Genotype PCs
PPM007754 PGS000998
(GBE_QT_FC1001697)
PSS007577|
East Asian Ancestry|
1,574 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative height size at age 10 : 0.05189 [0.03143, 0.07236]
Incremental R2 (full-covars): 0.02937
PGS R2 (no covariates): 0.03568 [0.01842, 0.05294]
age, sex, UKB array type, Genotype PCs
PPM007755 PGS000998
(GBE_QT_FC1001697)
PSS007578|
European Ancestry|
24,391 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative height size at age 10 : 0.1366 [0.12868, 0.14453]
Incremental R2 (full-covars): 0.12631
PGS R2 (no covariates): 0.13848 [0.13052, 0.14644]
age, sex, UKB array type, Genotype PCs
PPM007756 PGS000998
(GBE_QT_FC1001697)
PSS007579|
South Asian Ancestry|
7,225 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative height size at age 10 : 0.05926 [0.04912, 0.0694]
Incremental R2 (full-covars): 0.05228
PGS R2 (no covariates): 0.05606 [0.04617, 0.06596]
age, sex, UKB array type, Genotype PCs
PPM007757 PGS000998
(GBE_QT_FC1001697)
PSS007580|
European Ancestry|
66,430 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative height size at age 10 : 0.1468 [0.14186, 0.15173]
Incremental R2 (full-covars): 0.14445
PGS R2 (no covariates): 0.14612 [0.1412, 0.15105]
age, sex, UKB array type, Genotype PCs
PPM007758 PGS000999
(GBE_QT_FC1001687)
PSS007571|
African Ancestry|
5,987 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative body size at age 10 : 0.00794 [0.00364, 0.01223]
Incremental R2 (full-covars): 5e-05
PGS R2 (no covariates): 0.00274 [0.0002, 0.00527]
age, sex, UKB array type, Genotype PCs
PPM007759 PGS000999
(GBE_QT_FC1001687)
PSS007572|
East Asian Ancestry|
1,568 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative body size at age 10 : 0.02263 [0.0087, 0.03657]
Incremental R2 (full-covars): 0.01234
PGS R2 (no covariates): 0.01384 [0.00284, 0.02483]
age, sex, UKB array type, Genotype PCs
PPM007760 PGS000999
(GBE_QT_FC1001687)
PSS007573|
European Ancestry|
24,369 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative body size at age 10 : 0.05659 [0.05101, 0.06216]
Incremental R2 (full-covars): 0.05131
PGS R2 (no covariates): 0.0515 [0.04615, 0.05684]
age, sex, UKB array type, Genotype PCs
PPM007761 PGS000999
(GBE_QT_FC1001687)
PSS007574|
South Asian Ancestry|
7,142 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative body size at age 10 Incremental R2 (full-covars): 0.01063
: 0.01573 [0.01026, 0.02119]
PGS R2 (no covariates): 0.01201 [0.00722, 0.0168]
age, sex, UKB array type, Genotype PCs
PPM007762 PGS000999
(GBE_QT_FC1001687)
PSS007575|
European Ancestry|
66,372 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Comparative body size at age 10 : 0.06039 [0.05691, 0.06388]
Incremental R2 (full-covars): 0.05578
PGS R2 (no covariates): 0.05527 [0.05191, 0.05862]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000847 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 3,997 individuals Mean = 17.8 years European ALSPAC ALSPAC offspring
PSS000848 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 2,199 individuals,
0.0 % Male samples
Mean = 50.8 years European ALSPAC ALSPAC mothers
PSS000849 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 5,898 individuals Mean = 9.9 years European ALSPAC ALSPAC offspring
PSS007571 5,987 individuals African unspecified UKB
PSS007572 1,568 individuals East Asian UKB
PSS007573 24,369 individuals European non-white British ancestry UKB
PSS007574 7,142 individuals South Asian UKB
PSS007575 66,372 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007576 6,049 individuals African unspecified UKB
PSS007577 1,574 individuals East Asian UKB
PSS007578 24,391 individuals European non-white British ancestry UKB
PSS007579 7,225 individuals South Asian UKB
PSS007580 66,430 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS000875 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 37 cases
  • , 3,087 controls
]
European HUNT
PSS000876 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 344 cases
  • , 2,780 controls
]
European HUNT
PSS000877 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 30 cases
  • , 2,866 controls
]
European HUNT
PSS000878 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 274 cases
  • , 2,622 controls
]
European HUNT
PSS000879 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 542 cases
  • , 11,637 controls
]
European HUNT
PSS000880 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 2,898 cases
  • , 9,281 controls
]
European HUNT
PSS000881 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 1,240 cases
  • , 15,899 controls
]
European HUNT
PSS000882 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 5,775 cases
  • , 11,364 controls
]
European HUNT
PSS000883 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 15,112 cases
  • , 47,429 controls
]
European HUNT
PSS000884 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 43,408 cases
  • , 19,133 controls
]
European HUNT