Polygenic Score (PGS) ID: PGS001002

Predicted Trait
Reported Trait Whole body water mass
Mapped Trait(s) whole body water mass (EFO_0009805)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI23102
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI23102
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 35,046
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
265,179 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 265,179 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007773 PSS005051|
African Ancestry|
6,305 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Whole body water mass — — R²: 0.59835 [0.58325, 0.61345]
Incremental R2 (full-covars): 0.01006
PGS R2 (no covariates): 0.01762 [0.01128, 0.02396]		 age, sex, UKB array type, Genotype PCs —
PPM007774 PSS005052|
East Asian Ancestry|
1,680 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Whole body water mass — — R²: 0.74997 [0.72945, 0.77049]
Incremental R2 (full-covars): 0.00739
PGS R2 (no covariates): 0.0184 [0.00578, 0.03102]		 age, sex, UKB array type, Genotype PCs —
PPM007775 PSS005053|
European Ancestry|
24,466 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Whole body water mass — — R²: 0.75696 [0.7517, 0.76221]
Incremental R2 (full-covars): 0.04635
PGS R2 (no covariates): 0.04558 [0.04052, 0.05064]		 age, sex, UKB array type, Genotype PCs —
PPM007776 PSS005054|
South Asian Ancestry|
7,649 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Whole body water mass — — R²: 0.6942 [0.68292, 0.70548]
Incremental R2 (full-covars): 0.03631
PGS R2 (no covariates): 0.02751 [0.02037, 0.03465]		 age, sex, UKB array type, Genotype PCs —
PPM007777 PSS005055|
European Ancestry|
66,264 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Whole body water mass — — R²: 0.75779 [0.75461, 0.76097]
Incremental R2 (full-covars): 0.05245
PGS R2 (no covariates): 0.05076 [0.04753, 0.05399]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005052 — — 1,680 individuals — East Asian — UKB —
PSS005053 — — 24,466 individuals — European non-white British ancestry UKB —
PSS005054 — — 7,649 individuals — South Asian — UKB —
PSS005055 — — 66,264 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS005051 — — 6,305 individuals — African unspecified — UKB —