Polygenic Score (PGS) ID: PGS001022

Predicted Trait
Reported Trait Worry too long after an embarrassing experience
Mapped Trait(s) worry measurement (EFO_0009589)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN2000
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN2000
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 7,714
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
259,878 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 127,412 cases
  • , 132,466 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007873 PSS003647|
African Ancestry|
6,089 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.56572 [0.55125, 0.58019] R²: 0.01766
Incremental AUROC (full-covars): -0.00878
PGS R2 (no covariates): 0.00047
PGS AUROC (no covariates): 0.50946 [0.49481, 0.52411]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007874 PSS003648|
East Asian Ancestry|
1,530 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.56492 [0.5358, 0.59403] R²: 0.01813
Incremental AUROC (full-covars): -0.0008
PGS R2 (no covariates): 0.00097
PGS AUROC (no covariates): 0.52058 [0.49125, 0.5499]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007875 PSS003649|
European Ancestry|
23,849 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.58127 [0.57406, 0.58848] R²: 0.02677
Incremental AUROC (full-covars): 0.01383
PGS R2 (no covariates): 0.00912
PGS AUROC (no covariates): 0.54606 [0.53877, 0.55335]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007876 PSS003650|
South Asian Ancestry|
6,993 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.56486 [0.55147, 0.57825] R²: 0.01811
Incremental AUROC (full-covars): 0.00478
PGS R2 (no covariates): 0.00488
PGS AUROC (no covariates): 0.53067 [0.51717, 0.54417]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007877 PSS003651|
European Ancestry|
64,908 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.59904 [0.5947, 0.60337] R²: 0.03927
Incremental AUROC (full-covars): 0.01689
PGS R2 (no covariates): 0.01075
PGS AUROC (no covariates): 0.55091 [0.5465, 0.55532]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003647 — —
[
  • 2,619 cases
  • , 3,470 controls
]
 — African unspecified — UKB —
PSS003648 — —
[
  • 605 cases
  • , 925 controls
]
 — East Asian — UKB —
PSS003649 — —
[
  • 11,647 cases
  • , 12,202 controls
]
 — European non-white British ancestry UKB —
PSS003650 — —
[
  • 3,557 cases
  • , 3,436 controls
]
 — South Asian — UKB —
PSS003651 — —
[
  • 31,708 cases
  • , 33,200 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)