Trait: worry measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009589
Description Quantification of whether an individual feels or felt worried.
Trait category
Other measurement
Mapped term PMID:29500382

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001021
(GBE_BIN1980)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Feelings of worry or anxiety worry measurement,
anxiety measurement		 9,747
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001021/ScoringFiles/PGS001021.txt.gz
PGS001022
(GBE_BIN2000)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Worry too long after an embarrassing experience worry measurement 7,714
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001022/ScoringFiles/PGS001022.txt.gz
PGS001920
(portability-PLR_foreboding_feelings)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Recent feelings of foreboding worry measurement 2,894
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001920/ScoringFiles/PGS001920.txt.gz
PGS002136
(portability-ldpred2_foreboding_feelings)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Recent feelings of foreboding worry measurement 733,839
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002136/ScoringFiles/PGS002136.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007868 PGS001021
(GBE_BIN1980)
 PSS003642|
African Ancestry|
6,104 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.60438 [0.59021, 0.61855] R²: 0.04352
Incremental AUROC (full-covars): -0.00571
PGS R2 (no covariates): 0.00129
PGS AUROC (no covariates): 0.51656 [0.50201, 0.53111]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007869 PGS001021
(GBE_BIN1980)
 PSS003643|
East Asian Ancestry|
1,544 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.58907 [0.5608, 0.61733] R²: 0.03544
Incremental AUROC (full-covars): 0.01078
PGS R2 (no covariates): 0.0074
PGS AUROC (no covariates): 0.54082 [0.51208, 0.56956]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007870 PGS001021
(GBE_BIN1980)
 PSS003644|
European Ancestry|
24,170 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.6078 [0.60064, 0.61496] R²: 0.04664
Incremental AUROC (full-covars): 0.01418
PGS R2 (no covariates): 0.01254
PGS AUROC (no covariates): 0.55518 [0.54786, 0.56249]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007871 PGS001021
(GBE_BIN1980)
 PSS003645|
South Asian Ancestry|
7,170 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.59978 [0.58669, 0.61287] R²: 0.03875
Incremental AUROC (full-covars): -0.00373
PGS R2 (no covariates): 0.00244
PGS AUROC (no covariates): 0.5253 [0.51187, 0.53873]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007872 PGS001021
(GBE_BIN1980)
 PSS003646|
European Ancestry|
65,798 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.6164 [0.61209, 0.62072] R²: 0.05295
Incremental AUROC (full-covars): 0.0259
PGS R2 (no covariates): 0.01465
PGS AUROC (no covariates): 0.55972 [0.5553, 0.56414]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007873 PGS001022
(GBE_BIN2000)
 PSS003647|
African Ancestry|
6,089 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.56572 [0.55125, 0.58019] R²: 0.01766
Incremental AUROC (full-covars): -0.00878
PGS R2 (no covariates): 0.00047
PGS AUROC (no covariates): 0.50946 [0.49481, 0.52411]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007874 PGS001022
(GBE_BIN2000)
 PSS003648|
East Asian Ancestry|
1,530 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.56492 [0.5358, 0.59403] R²: 0.01813
Incremental AUROC (full-covars): -0.0008
PGS R2 (no covariates): 0.00097
PGS AUROC (no covariates): 0.52058 [0.49125, 0.5499]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007875 PGS001022
(GBE_BIN2000)
 PSS003649|
European Ancestry|
23,849 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.58127 [0.57406, 0.58848] R²: 0.02677
Incremental AUROC (full-covars): 0.01383
PGS R2 (no covariates): 0.00912
PGS AUROC (no covariates): 0.54606 [0.53877, 0.55335]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007876 PGS001022
(GBE_BIN2000)
 PSS003650|
South Asian Ancestry|
6,993 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.56486 [0.55147, 0.57825] R²: 0.01811
Incremental AUROC (full-covars): 0.00478
PGS R2 (no covariates): 0.00488
PGS AUROC (no covariates): 0.53067 [0.51717, 0.54417]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007877 PGS001022
(GBE_BIN2000)
 PSS003651|
European Ancestry|
64,908 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worry too long after embarrassment — AUROC: 0.59904 [0.5947, 0.60337] R²: 0.03927
Incremental AUROC (full-covars): 0.01689
PGS R2 (no covariates): 0.01075
PGS AUROC (no covariates): 0.55091 [0.5465, 0.55532]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM010239 PGS001920
(portability-PLR_foreboding_feelings)
 PSS009407|
European Ancestry|
6,430 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0282 [0.0037, 0.0526] sex, age, birth date, deprivation index, 16 PCs —
PPM010240 PGS001920
(portability-PLR_foreboding_feelings)
 PSS009181|
European Ancestry|
1,238 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0479 [-0.0082, 0.1038] sex, age, birth date, deprivation index, 16 PCs —
PPM010241 PGS001920
(portability-PLR_foreboding_feelings)
 PSS008735|
European Ancestry|
2,246 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0291 [-0.0125, 0.0705] sex, age, birth date, deprivation index, 16 PCs —
PPM010242 PGS001920
(portability-PLR_foreboding_feelings)
 PSS008509|
Greater Middle Eastern Ancestry|
198 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0194 [-0.1661, 0.128] sex, age, birth date, deprivation index, 16 PCs —
PPM010243 PGS001920
(portability-PLR_foreboding_feelings)
 PSS008287|
South Asian Ancestry|
807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1152 [0.0457, 0.1837] sex, age, birth date, deprivation index, 16 PCs —
PPM010244 PGS001920
(portability-PLR_foreboding_feelings)
 PSS008064|
East Asian Ancestry|
421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0358 [-0.1333, 0.0623] sex, age, birth date, deprivation index, 16 PCs —
PPM010245 PGS001920
(portability-PLR_foreboding_feelings)
 PSS007851|
African Ancestry|
370 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1352 [0.0308, 0.2367] sex, age, birth date, deprivation index, 16 PCs —
PPM010246 PGS001920
(portability-PLR_foreboding_feelings)
 PSS008955|
African Ancestry|
507 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0521 [-0.1403, 0.0369] sex, age, birth date, deprivation index, 16 PCs —
PPM030665 PGS001920
(portability-PLR_foreboding_feelings)
 PSS012230|
Greater Middle Eastern Ancestry|
1,359 individuals
 PGP000795 |
Smeeth D et al. Dev Psychopathol (2023)
|Ext.		 Reported Trait: Resilience OR: 0.01 [0.0, 0.62] — — age, gender,10 genetic principal components, war exposure —
PPM011939 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS009407|
European Ancestry|
6,430 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0695 [0.0451, 0.0939] sex, age, birth date, deprivation index, 16 PCs —
PPM011940 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS009181|
European Ancestry|
1,238 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0131 [-0.0431, 0.0692] sex, age, birth date, deprivation index, 16 PCs —
PPM011941 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS008735|
European Ancestry|
2,246 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0387 [-0.0029, 0.0801] sex, age, birth date, deprivation index, 16 PCs —
PPM011942 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS008509|
Greater Middle Eastern Ancestry|
198 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0313 [-0.1163, 0.1776] sex, age, birth date, deprivation index, 16 PCs —
PPM011943 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS008287|
South Asian Ancestry|
807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1037 [0.0341, 0.1724] sex, age, birth date, deprivation index, 16 PCs —
PPM011944 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS008064|
East Asian Ancestry|
421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0664 [-0.0318, 0.1632] sex, age, birth date, deprivation index, 16 PCs —
PPM011945 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS007851|
African Ancestry|
370 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1369 [0.0325, 0.2383] sex, age, birth date, deprivation index, 16 PCs —
PPM011946 PGS002136
(portability-ldpred2_foreboding_feelings)
 PSS008955|
African Ancestry|
507 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0109 [-0.0997, 0.078] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003644 — —
[
  • 13,973 cases
  • , 10,197 controls
]
 — European non-white British ancestry UKB —
PSS003645 — —
[
  • 3,970 cases
  • , 3,200 controls
]
 — South Asian — UKB —
PSS003646 — —
[
  • 37,860 cases
  • , 27,938 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS003647 — —
[
  • 2,619 cases
  • , 3,470 controls
]
 — African unspecified — UKB —
PSS003648 — —
[
  • 605 cases
  • , 925 controls
]
 — East Asian — UKB —
PSS003649 — —
[
  • 11,647 cases
  • , 12,202 controls
]
 — European non-white British ancestry UKB —
PSS003650 — —
[
  • 3,557 cases
  • , 3,436 controls
]
 — South Asian — UKB —
PSS003651 — —
[
  • 31,708 cases
  • , 33,200 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS012230 — — 1,359 individuals,
47.24 % Male samples
 Mean = 11.23 years
Sd = 2.39 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Syrian)		 — BIOPATH —
PSS009181 — — 1,238 individuals — European Poland (NE Europe) UKB —
PSS008287 — — 807 individuals — South Asian India (South Asia) UKB —
PSS008955 — — 507 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008064 — — 421 individuals — East Asian China (East Asia) UKB —
PSS008735 — — 2,246 individuals — European Italy (South Europe) UKB —
PSS007851 — — 370 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008509 — — 198 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009407 — — 6,430 individuals — European UK (+ Ireland) UKB —
PSS003642 — —
[
  • 2,702 cases
  • , 3,402 controls
]
 — African unspecified — UKB —
PSS003643 — —
[
  • 746 cases
  • , 798 controls
]
 — East Asian — UKB —