Polygenic Score (PGS) ID: PGS001790

Predicted Trait
Reported Trait Heart Failure
Mapped Trait(s) heart failure (EFO_0003144)
Released in PGS Catalog: Sept. 8, 2022
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Score Details

Score Construction
PGS Name 1kgeur_gbmi_leaveUKBBout_HF_pst_eff_a1_b0.5_phiauto
Development Method
Name PRS-CS-auto
Parameters effective sample size and other defualt parameters
Variants
Original Genome Build GRCh37
Number of Variants 910,146
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000262
Citation (link to publication) Wang Y et al. medRxiv (2021) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 65.3%
East Asian: 28%
African: 2.7%
Additional Asian Ancestries: 2.4%
Additional Diverse Ancestries: 1.6%
919,746 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
[
  • 1,260 cases
  • , 23,339 controls
]
African unspecified G&H
[
  • 1,170 cases
  • , 13,217 controls
]
Native American BioMe, UCLA
[
  • 12,665 cases
  • , 245,263 controls
]
East Asian BioMe, UCLA
[
  • 45,045 cases
  • , 555,839 controls
]
European BBJ, CKB, UCLA
[
  • 465 cases
  • , 21,483 controls
]
Asian unspecified 10 cohorts
  • BioMe
  • ,BioVU
  • ,CCPM
  • ,EB
  • ,FinnGen
  • ,GS:SFHS
  • ,HUNT
  • ,MGBB
  • ,MGI
  • ,UCLA

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009294 PSS007713|
European Ancestry|
358,905 individuals
PGP000262 |
Wang Y et al. medRxiv (2021)
|Pre
Reported Trait: Heart Failure AUROC: 0.75 Nagelkerke's R2 (covariates regressed out): 0.00698 sex,age,age2,age*sex,age^2*sex, 20PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007713
[
  • 6,285 cases
  • , 352,619 controls
]
European UKB