Polygenic Score (PGS) ID: PGS001902

Predicted Trait
Reported Trait P duration
Mapped Trait(s) P wave duration (EFO_0005094)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_ECG_P_duration
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 640
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010099 PSS009365|
European Ancestry|
1,622 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.0975 [0.0487, 0.1458] sex, age, birth date, deprivation index, 16 PCs
PPM010100 PSS009139|
European Ancestry|
310 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.1126 [-0.0026, 0.2249] sex, age, birth date, deprivation index, 16 PCs
PPM010101 PSS008693|
European Ancestry|
474 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.0776 [-0.0146, 0.1684] sex, age, birth date, deprivation index, 16 PCs
PPM010102 PSS008467|
Greater Middle Eastern Ancestry|
49 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): -0.1487 [-0.4886, 0.2303] sex, age, birth date, deprivation index, 16 PCs
PPM010103 PSS008247|
South Asian Ancestry|
299 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.0714 [-0.0464, 0.1872] sex, age, birth date, deprivation index, 16 PCs
PPM010104 PSS008025|
East Asian Ancestry|
134 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.2031 [0.0199, 0.3731] sex, age, birth date, deprivation index, 16 PCs
PPM010105 PSS007811|
African Ancestry|
76 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.2803 [0.0188, 0.5059] sex, age, birth date, deprivation index, 16 PCs
PPM010106 PSS008915|
African Ancestry|
138 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: P duration Partial Correlation (partial-r): 0.1764 [-0.0045, 0.3461] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008467 49 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009139 310 individuals European Poland (NE Europe) UKB
PSS009365 1,622 individuals European UK (+ Ireland) UKB
PSS008693 474 individuals European Italy (South Europe) UKB
PSS008247 299 individuals South Asian India (South Asia) UKB
PSS008915 138 individuals African unspecified Nigeria (West Africa) UKB
PSS008025 134 individuals East Asian China (East Asia) UKB
PSS007811 76 individuals African American or Afro-Caribbean Carribean UKB