Polygenic Score (PGS) ID: PGS001920

Predicted Trait
Reported Trait Recent feelings of foreboding
Mapped Trait(s) worry measurement (EFO_0009589)
Additional Trait Information psychiatric disorders
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_foreboding_feelings
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 2,894
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 33.3%
African: 22.2%
Greater Middle Eastern: 22.2%
East Asian: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010239 PSS009407|
European Ancestry|
6,430 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0282 [0.0037, 0.0526] sex, age, birth date, deprivation index, 16 PCs —
PPM010240 PSS009181|
European Ancestry|
1,238 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0479 [-0.0082, 0.1038] sex, age, birth date, deprivation index, 16 PCs —
PPM010241 PSS008735|
European Ancestry|
2,246 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0291 [-0.0125, 0.0705] sex, age, birth date, deprivation index, 16 PCs —
PPM010242 PSS008509|
Greater Middle Eastern Ancestry|
198 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0194 [-0.1661, 0.128] sex, age, birth date, deprivation index, 16 PCs —
PPM010243 PSS008287|
South Asian Ancestry|
807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1152 [0.0457, 0.1837] sex, age, birth date, deprivation index, 16 PCs —
PPM010244 PSS008064|
East Asian Ancestry|
421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0358 [-0.1333, 0.0623] sex, age, birth date, deprivation index, 16 PCs —
PPM010245 PSS007851|
African Ancestry|
370 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1352 [0.0308, 0.2367] sex, age, birth date, deprivation index, 16 PCs —
PPM010246 PSS008955|
African Ancestry|
507 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0521 [-0.1403, 0.0369] sex, age, birth date, deprivation index, 16 PCs —
PPM030665 PSS012230|
Greater Middle Eastern Ancestry|
1,359 individuals
 PGP000795 |
Smeeth D et al. Dev Psychopathol (2023)
|Ext.		 Reported Trait: Resilience OR: 0.01 [0.0, 0.62] — — age, gender,10 genetic principal components, war exposure —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007851 — — 370 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008287 — — 807 individuals — South Asian India (South Asia) UKB —
PSS012230 — — 1,359 individuals,
47.24 % Male samples
 Mean = 11.23 years
Sd = 2.39 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Syrian)		 — BIOPATH —
PSS009407 — — 6,430 individuals — European UK (+ Ireland) UKB —
PSS008955 — — 507 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008509 — — 198 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008735 — — 2,246 individuals — European Italy (South Europe) UKB —
PSS008064 — — 421 individuals — East Asian China (East Asia) UKB —
PSS009181 — — 1,238 individuals — European Poland (NE Europe) UKB —