Polygenic Score (PGS) ID: PGS001936

Predicted Trait
Reported Trait General happiness
Mapped Trait(s) wellbeing measurement (EFO_0007869)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_less_happy
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 10,628
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010363 PSS009422|
European Ancestry|
6,429 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): 0.0697 [0.0453, 0.094] sex, age, birth date, deprivation index, 16 PCs
PPM010364 PSS009196|
European Ancestry|
1,241 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): 0.0305 [-0.0257, 0.0864] sex, age, birth date, deprivation index, 16 PCs
PPM010365 PSS008750|
European Ancestry|
2,243 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): 0.0421 sex, age, birth date, deprivation index, 16 PCs
PPM010366 PSS008524|
Greater Middle Eastern Ancestry|
199 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): -0.1188 [-0.2609, 0.0284] sex, age, birth date, deprivation index, 16 PCs
PPM010367 PSS008302|
South Asian Ancestry|
809 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): 0.005 [-0.0648, 0.0748] sex, age, birth date, deprivation index, 16 PCs
PPM010368 PSS008079|
East Asian Ancestry|
424 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): 0.0412 [-0.0566, 0.1382] sex, age, birth date, deprivation index, 16 PCs
PPM010369 PSS007866|
African Ancestry|
368 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): -0.0999 [-0.2029, 0.0053] sex, age, birth date, deprivation index, 16 PCs
PPM010370 PSS008970|
African Ancestry|
503 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: General happiness Partial Correlation (partial-r): 0.0139 [-0.0754, 0.103] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008970 503 individuals African unspecified Nigeria (West Africa) UKB
PSS009196 1,241 individuals European Poland (NE Europe) UKB
PSS008524 199 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009422 6,429 individuals European UK (+ Ireland) UKB
PSS008750 2,243 individuals European Italy (South Europe) UKB
PSS008302 809 individuals South Asian India (South Asia) UKB
PSS008079 424 individuals East Asian China (East Asia) UKB
PSS007866 368 individuals African American or Afro-Caribbean Carribean UKB