Polygenic Score (PGS) ID: PGS001988

Predicted Trait
Reported Trait Testosterone (male only)
Mapped Trait(s)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_M_log_testosterone
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 3,985
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010779 PSS009380|
European Ancestry|
7,947 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.1448 [0.1232, 0.1663] sex, age, birth date, deprivation index, 16 PCs
PPM010780 PSS009154|
European Ancestry|
1,666 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.1145 [0.0665, 0.1619] sex, age, birth date, deprivation index, 16 PCs
PPM010781 PSS008708|
European Ancestry|
2,641 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.1082 [0.0702, 0.1459] sex, age, birth date, deprivation index, 16 PCs
PPM010782 PSS008482|
Greater Middle Eastern Ancestry|
485 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.1329 [0.0425, 0.2212] sex, age, birth date, deprivation index, 16 PCs
PPM010783 PSS008260|
South Asian Ancestry|
2,486 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.1284 [0.0893, 0.167] sex, age, birth date, deprivation index, 16 PCs
PPM010784 PSS008038|
East Asian Ancestry|
742 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.0942 [0.0214, 0.1661] sex, age, birth date, deprivation index, 16 PCs
PPM010786 PSS008928|
African Ancestry|
1,551 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.0262 [-0.0239, 0.0762] sex, age, birth date, deprivation index, 16 PCs
PPM010785 PSS007824|
African Ancestry|
973 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Testosterone (male only) Partial Correlation (partial-r): 0.0604 [-0.0031, 0.1234] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009380 7,947 individuals European UK (+ Ireland) UKB
PSS008708 2,641 individuals European Italy (South Europe) UKB
PSS008260 2,486 individuals South Asian India (South Asia) UKB
PSS008038 742 individuals East Asian China (East Asia) UKB
PSS007824 973 individuals African American or Afro-Caribbean Carribean UKB
PSS009154 1,666 individuals European Poland (NE Europe) UKB
PSS008928 1,551 individuals African unspecified Nigeria (West Africa) UKB
PSS008482 485 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB