Polygenic Score (PGS) ID: PGS001991

Predicted Trait
Reported Trait Monocyte percentage
Mapped Trait(s) monocyte percentage of leukocytes (EFO_0007989)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-PLR_monocyte_perc
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 41,887
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
391,124 individuals European UK (+ Ireland) UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010803 PSS009474|
European Ancestry|
19,244 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.4126 [0.4008, 0.4243] sex, age, birth date, deprivation index, 16 PCs
PPM010804 PSS009248|
European Ancestry|
3,963 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.4017 [0.3752, 0.4276] sex, age, birth date, deprivation index, 16 PCs
PPM010805 PSS008802|
European Ancestry|
6,368 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.4021 [0.3813, 0.4225] sex, age, birth date, deprivation index, 16 PCs
PPM010806 PSS008576|
Greater Middle Eastern Ancestry|
1,144 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.4032 [0.3531, 0.4511] sex, age, birth date, deprivation index, 16 PCs
PPM010807 PSS008354|
South Asian Ancestry|
6,010 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.3324 [0.3096, 0.3547] sex, age, birth date, deprivation index, 16 PCs
PPM010808 PSS008131|
East Asian Ancestry|
1,744 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.3106 [0.2673, 0.3526] sex, age, birth date, deprivation index, 16 PCs
PPM010809 PSS007918|
African Ancestry|
2,298 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.184 [0.1441, 0.2234] sex, age, birth date, deprivation index, 16 PCs
PPM010810 PSS009022|
African Ancestry|
3,663 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Monocyte percentage Partial Correlation (partial-r): 0.1696 [0.1379, 0.201] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009474 19,244 individuals European UK (+ Ireland) UKB
PSS007918 2,298 individuals African American or Afro-Caribbean Carribean UKB
PSS009248 3,963 individuals European Poland (NE Europe) UKB
PSS009022 3,663 individuals African unspecified Nigeria (West Africa) UKB
PSS008576 1,144 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008354 6,010 individuals South Asian India (South Asia) UKB
PSS008802 6,368 individuals European Italy (South Europe) UKB
PSS008131 1,744 individuals East Asian China (East Asia) UKB