Trait: monocyte percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007989
Description A calculated measurement in which the number of monocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • blood monocyte count to total leukocyte count ratio
  • monocyte count as percentage of total white blood cells
  • monocyte count to total WBC count ratio
  • monocyte percentage
  • monocyte percentage of white cells
Mapped term CMO:0000374

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000103
(mono_p)
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Monocyte percentage of white cells monocyte percentage of leukocytes 22,843
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000103/ScoringFiles/PGS000103.txt.gz
PGS000178
(mono_p)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Monocyte percentage of white cells monocyte percentage of leukocytes 549
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000178/ScoringFiles/PGS000178.txt.gz
PGS001078
(GBE_INI30190)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Monocyte percentage monocyte percentage of leukocytes 8,762
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001078/ScoringFiles/PGS001078.txt.gz
PGS001991
(portability-PLR_monocyte_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Monocyte percentage monocyte percentage of leukocytes 41,887
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001991/ScoringFiles/PGS001991.txt.gz
PGS002208
(portability-ldpred2_monocyte_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Monocyte percentage monocyte percentage of leukocytes 544,905
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002208/ScoringFiles/PGS002208.txt.gz
PGS003562
(cont-decay-monocyte_perc)
 PGP000457 |
Ding Y et al. Nature (2023)
 Monocyte percentage monocyte percentage of leukocytes 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003562/ScoringFiles/PGS003562.txt.gz
PGS003942
(INI30190)
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Monocyte percentage monocyte percentage of leukocytes 10,717
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003942/ScoringFiles/PGS003942.txt.gz
PGS004360
(X30190.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Monocyte percentage monocyte percentage of leukocytes 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004360/ScoringFiles/PGS004360.txt.gz
PGS005190
(VPGS_MONO_P)
 PGP000723 |
Xiang R et al. Nat Commun (2025)
 Monocyte percentage of white cells variance monocyte percentage of leukocytes 9,488,343
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005190/ScoringFiles/PGS005190.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000238 PGS000103
(mono_p)
 PSS000168|
European Ancestry|
80,627 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Monocyte percentage of white cells — — Pearson correlation coefficent (r): 0.46271 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000239 PGS000103
(mono_p)
 PSS000142|
European Ancestry|
39,189 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Monocyte percentage of white cells — — Pearson correlation coefficent (r): 0.45879 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) —
PPM000534 PGS000178
(mono_p)
 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Monocyte percentage of white cells — — R²: 0.14461 sex, age, 10 genetic PCs —
PPM008148 PGS001078
(GBE_INI30190)
 PSS006996|
African Ancestry|
6,120 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Monocyte % — — R²: 0.03107 [0.02277, 0.03938]
Incremental R2 (full-covars): 0.01068
PGS R2 (no covariates): 0.01162 [0.00644, 0.0168]		 age, sex, UKB array type, Genotype PCs —
PPM008149 PGS001078
(GBE_INI30190)
 PSS006997|
East Asian Ancestry|
1,654 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Monocyte % — — R²: 0.10068 [0.07364, 0.12772]
Incremental R2 (full-covars): 0.04628
PGS R2 (no covariates): 0.04808 [0.0283, 0.06786]		 age, sex, UKB array type, Genotype PCs —
PPM008150 PGS001078
(GBE_INI30190)
 PSS006998|
European Ancestry|
24,130 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Monocyte % — — R²: 0.12442 [0.11675, 0.13209]
Incremental R2 (full-covars): 0.08036
PGS R2 (no covariates): 0.08169 [0.07518, 0.08821]		 age, sex, UKB array type, Genotype PCs —
PPM008151 PGS001078
(GBE_INI30190)
 PSS006999|
South Asian Ancestry|
7,491 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Monocyte % — — R²: 0.12434 [0.11066, 0.13801]
Incremental R2 (full-covars): 0.05529
PGS R2 (no covariates): 0.05423 [0.04448, 0.06398]		 age, sex, UKB array type, Genotype PCs —
PPM008152 PGS001078
(GBE_INI30190)
 PSS007000|
European Ancestry|
65,520 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Monocyte % — — R²: 0.12757 [0.12287, 0.13228]
Incremental R2 (full-covars): 0.08527
PGS R2 (no covariates): 0.08574 [0.0817, 0.08978]		 age, sex, UKB array type, Genotype PCs —
PPM010803 PGS001991
(portability-PLR_monocyte_perc)
 PSS009474|
European Ancestry|
19,244 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4126 [0.4008, 0.4243] sex, age, birth date, deprivation index, 16 PCs —
PPM010804 PGS001991
(portability-PLR_monocyte_perc)
 PSS009248|
European Ancestry|
3,963 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4017 [0.3752, 0.4276] sex, age, birth date, deprivation index, 16 PCs —
PPM010805 PGS001991
(portability-PLR_monocyte_perc)
 PSS008802|
European Ancestry|
6,368 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4021 [0.3813, 0.4225] sex, age, birth date, deprivation index, 16 PCs —
PPM010806 PGS001991
(portability-PLR_monocyte_perc)
 PSS008576|
Greater Middle Eastern Ancestry|
1,144 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4032 [0.3531, 0.4511] sex, age, birth date, deprivation index, 16 PCs —
PPM010807 PGS001991
(portability-PLR_monocyte_perc)
 PSS008354|
South Asian Ancestry|
6,010 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3324 [0.3096, 0.3547] sex, age, birth date, deprivation index, 16 PCs —
PPM010808 PGS001991
(portability-PLR_monocyte_perc)
 PSS008131|
East Asian Ancestry|
1,744 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3106 [0.2673, 0.3526] sex, age, birth date, deprivation index, 16 PCs —
PPM010809 PGS001991
(portability-PLR_monocyte_perc)
 PSS007918|
African Ancestry|
2,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.184 [0.1441, 0.2234] sex, age, birth date, deprivation index, 16 PCs —
PPM010810 PGS001991
(portability-PLR_monocyte_perc)
 PSS009022|
African Ancestry|
3,663 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.1696 [0.1379, 0.201] sex, age, birth date, deprivation index, 16 PCs —
PPM012511 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS009474|
European Ancestry|
19,244 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4079 [0.396, 0.4196] sex, age, birth date, deprivation index, 16 PCs —
PPM012512 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS009248|
European Ancestry|
3,963 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3935 [0.3668, 0.4196] sex, age, birth date, deprivation index, 16 PCs —
PPM012513 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS008802|
European Ancestry|
6,368 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3978 [0.3769, 0.4183] sex, age, birth date, deprivation index, 16 PCs —
PPM012514 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS008576|
Greater Middle Eastern Ancestry|
1,144 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4047 [0.3546, 0.4524] sex, age, birth date, deprivation index, 16 PCs —
PPM012516 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS008131|
East Asian Ancestry|
1,744 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3023 [0.2587, 0.3445] sex, age, birth date, deprivation index, 16 PCs —
PPM012517 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS007918|
African Ancestry|
2,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.1887 [0.1488, 0.228] sex, age, birth date, deprivation index, 16 PCs —
PPM012518 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS009022|
African Ancestry|
3,663 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.1635 [0.1317, 0.1949] sex, age, birth date, deprivation index, 16 PCs —
PPM012515 PGS002208
(portability-ldpred2_monocyte_perc)
 PSS008354|
South Asian Ancestry|
6,010 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3313 [0.3085, 0.3536] sex, age, birth date, deprivation index, 16 PCs —
PPM017574 PGS003562
(cont-decay-monocyte_perc)
 PSS010845|
European Ancestry|
3,952 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017658 PGS003562
(cont-decay-monocyte_perc)
 PSS010677|
European Ancestry|
6,213 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017826 PGS003562
(cont-decay-monocyte_perc)
 PSS010257|
European Ancestry|
2,241 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017910 PGS003562
(cont-decay-monocyte_perc)
 PSS010509|
South Asian Ancestry|
5,958 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017994 PGS003562
(cont-decay-monocyte_perc)
 PSS010425|
East Asian Ancestry|
1,732 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM018078 PGS003562
(cont-decay-monocyte_perc)
 PSS010341|
African Ancestry|
2,285 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM018162 PGS003562
(cont-decay-monocyte_perc)
 PSS010761|
African Ancestry|
3,634 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017490 PGS003562
(cont-decay-monocyte_perc)
 PSS010929|
European Ancestry|
19,237 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017742 PGS003562
(cont-decay-monocyte_perc)
 PSS010593|
Greater Middle Eastern Ancestry|
1,114 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Monocyte percentage — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM019029 PGS003942
(INI30190)
 PSS011139|
European Ancestry|
65,814 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte percentage — — R²: 0.1281 [0.1234, 0.1328]
PGS R2 (no covariates): 0.08549 [0.08146, 0.08952]
Incremental R2 (full-covars): 0.0852		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019030 PGS003942
(INI30190)
 PSS011110|
European Ancestry|
2,810 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte percentage — — R²: 0.1222 [0.09987, 0.14453]
PGS R2 (no covariates): 0.08548 [0.06603, 0.10494]
Incremental R2 (full-covars): 0.08222		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019031 PGS003942
(INI30190)
 PSS011112|
South Asian Ancestry|
1,428 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte percentage — — R²: 0.15234 [0.11879, 0.18589]
PGS R2 (no covariates): 0.07059 [0.04555, 0.09563]
Incremental R2 (full-covars): 0.06921		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019032 PGS003942
(INI30190)
 PSS011154|
African Ancestry|
1,154 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte percentage — — R²: 0.03382 [0.01388, 0.05376]
PGS R2 (no covariates): 0.01755 [0.00294, 0.03215]
Incremental R2 (full-covars): 0.01822		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019033 PGS003942
(INI30190)
 PSS011168|
Multi-ancestry (excluding European)|
7,732 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte percentage — — R²: 0.08833 [0.07647, 0.1002]
PGS R2 (no covariates): 0.0562 [0.0464, 0.06599]
Incremental R2 (full-covars): 0.04903		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM020475 PGS004360
(X30190.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Monocyte percentage — — PGS R2 (no covariates): 0.24644 — —
PPM022550 PGS005190
(VPGS_MONO_P)
 PSS012001|
European Ancestry|
39,189 individuals
 PGP000723 |
Xiang R et al. Nat Commun (2025)
 Reported Trait: Monocyte_percentage_of_white_cells β: 0.00025 — R²: 0.20758 — effects of PGS*vPGS tested and shown in Supplementary Data 12)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011154 — — 1,154 individuals — African unspecified — UKB —
PSS010929 — — 19,237 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010677 — — 6,213 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS006996 — — 6,120 individuals — African unspecified — UKB —
PSS006997 — — 1,654 individuals — East Asian — UKB —
PSS006998 — — 24,130 individuals — European non-white British ancestry UKB —
PSS006999 — — 7,491 individuals — South Asian — UKB —
PSS007000 — — 65,520 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010425 — — 1,732 individuals,
34.0 % Male samples
 Mean = 52.5 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS008802 — — 6,368 individuals — European Italy (South Europe) UKB —
PSS011168 — — 7,732 individuals — East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB —
PSS012001 — — 39,189 individuals — European
(British)		 — INTERVAL —
PSS011139 — — 65,814 individuals — European
(white British ancestry)		 — UKB —
PSS000291 — — 39,260 individuals — European — INTERVAL —
PSS007918 — — 2,298 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008576 — — 1,144 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009474 — — 19,244 individuals — European UK (+ Ireland) UKB —
PSS010845 — — 3,952 individuals,
38.0 % Male samples
 Mean = 54.3 years
Sd = 7.5 years		 European Polish UKB —
PSS010593 — — 1,114 individuals,
60.0 % Male samples
 Mean = 52.0 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010341 — — 2,285 individuals,
37.0 % Male samples
 Mean = 52.4 years
Sd = 8.0 years		 African American or Afro-Caribbean Caribbean UKB —
PSS000142 — — 39,189 individuals,
50.0 % Male samples
 Mean = 43.83 years
Range = [18.0, 76.4] years		 European — INTERVAL —
PSS011364 — — 56,192 individuals — European — UKB —
PSS009248 — — 3,963 individuals — European Poland (NE Europe) UKB —
PSS008354 — — 6,010 individuals — South Asian India (South Asia) UKB —
PSS011110 — — 2,810 individuals — European
(non-white British ancestry)		 — UKB —
PSS000168 — — 80,627 individuals,
46.0 % Male samples
 Mean = 57.23 years
Range = [40.19, 71.1] years		 European — UKB —
PSS011112 — — 1,428 individuals — South Asian — UKB —
PSS010761 — — 3,634 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010509 — — 5,958 individuals,
55.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010257 — — 2,241 individuals,
45.0 % Male samples
 Mean = 58.0 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS009022 — — 3,663 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008131 — — 1,744 individuals — East Asian China (East Asia) UKB —