Polygenic Score (PGS) ID: PGS002136

Predicted Trait
Reported Trait Recent feelings of foreboding
Mapped Trait(s) worry measurement (EFO_0009589)
Additional Trait Information psychiatric disorders
Released in PGS Catalog: Jan. 10, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-ldpred2_foreboding_feelings
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 733,839
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011939 PSS009407|
European Ancestry|
6,430 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0695 [0.0451, 0.0939] sex, age, birth date, deprivation index, 16 PCs —
PPM011940 PSS009181|
European Ancestry|
1,238 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0131 [-0.0431, 0.0692] sex, age, birth date, deprivation index, 16 PCs —
PPM011941 PSS008735|
European Ancestry|
2,246 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0387 [-0.0029, 0.0801] sex, age, birth date, deprivation index, 16 PCs —
PPM011942 PSS008509|
Greater Middle Eastern Ancestry|
198 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0313 [-0.1163, 0.1776] sex, age, birth date, deprivation index, 16 PCs —
PPM011943 PSS008287|
South Asian Ancestry|
807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1037 [0.0341, 0.1724] sex, age, birth date, deprivation index, 16 PCs —
PPM011944 PSS008064|
East Asian Ancestry|
421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.0664 [-0.0318, 0.1632] sex, age, birth date, deprivation index, 16 PCs —
PPM011945 PSS007851|
African Ancestry|
370 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): 0.1369 [0.0325, 0.2383] sex, age, birth date, deprivation index, 16 PCs —
PPM011946 PSS008955|
African Ancestry|
507 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Recent feelings of foreboding — — Partial Correlation (partial-r): -0.0109 [-0.0997, 0.078] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007851 — — 370 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008287 — — 807 individuals — South Asian India (South Asia) UKB —
PSS009407 — — 6,430 individuals — European UK (+ Ireland) UKB —
PSS008955 — — 507 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008509 — — 198 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008735 — — 2,246 individuals — European Italy (South Europe) UKB —
PSS008064 — — 421 individuals — East Asian China (East Asia) UKB —
PSS009181 — — 1,238 individuals — European Poland (NE Europe) UKB —