| Predicted Trait | |
| Reported Trait | Childhood asthma |
| Mapped Trait(s) | childhood onset asthma (MONDO_0005405) |
| Score Construction | |
| PGS Name | PRSice_asthma |
| Development Method | |
| Name | PRSice (C+T) |
| Parameters | r2<0.1 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 105 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000275 |
| Citation (link to publication) | Kothalawala DM et al. J Pers Med (2022) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST007800 Europe PMC: 30929738 |
314,633 individuals | European | UKB |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | [
|
European | NR | School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last | — | — | — | — |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM012792 | PSS009557| European Ancestry| 898 individuals |
PGP000275 | Kothalawala DM et al. J Pers Med (2022) |
Reported Trait: Childhood asthma by age 11 | — | AUROC: 0.61 | — | — | — |
| PPM012793 | PSS009558| European Ancestry| 1,018 individuals |
PGP000275 | Kothalawala DM et al. J Pers Med (2022) |
Reported Trait: Childhood asthma by age 8 | — | AUROC: 0.65 [0.53, 0.77] | — | CAPE model | — |
| PPM012791 | PSS009558| European Ancestry| 1,018 individuals |
PGP000275 | Kothalawala DM et al. J Pers Med (2022) |
Reported Trait: Childhood asthma by age 8 | — | AUROC: 0.61 | — | — | — |
| PPM012794 | PSS009557| European Ancestry| 898 individuals |
PGP000275 | Kothalawala DM et al. J Pers Med (2022) |
Reported Trait: Childhood asthma by age 11 | — | AUROC: 0.71 [0.61, 0.8] | — | CAPE model | — |
| PPM012795 | PSS009558| European Ancestry| 1,018 individuals |
PGP000275 | Kothalawala DM et al. J Pers Med (2022) |
Reported Trait: Childhood asthma by age 8 | — | AUROC: 0.85 [0.77, 0.92] | — | CAPP model | — |
| PPM012796 | PSS009557| European Ancestry| 898 individuals |
PGP000275 | Kothalawala DM et al. J Pers Med (2022) |
Reported Trait: Childhood asthma by age 11 | — | AUROC: 0.81 [0.72, 0.89] | — | CAPP model | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009558 | School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last | — | [
|
— | European | — | MAAS | — |
| PSS009557 | School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last | — | [
|
— | European | — | MAAS | — |