Trait: childhood onset asthma

Trait Information
Identifier MONDO_0005405
Description Asthma that starts in childhood. [EFO: 0004591]
Trait category
Other disease
Synonyms 4 synonyms
  • asthma of childhood
  • childhood asthma
  • paediatric asthma
  • pediatric asthma
Mapped terms 4 mapped terms
  • DOID:0080815
  • EFO:0004591
  • SCTID:233678006
  • UMLS:C0264408

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002248
(PRSice_asthma)
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Childhood asthma childhood onset asthma 105
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002248/ScoringFiles/PGS002248.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012792 PGS002248
(PRSice_asthma)
PSS009557|
European Ancestry|
898 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 11 AUROC: 0.61
PPM012793 PGS002248
(PRSice_asthma)
PSS009558|
European Ancestry|
1,018 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 8 AUROC: 0.65 [0.53, 0.77] CAPE model
PPM012791 PGS002248
(PRSice_asthma)
PSS009558|
European Ancestry|
1,018 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 8 AUROC: 0.61
PPM012794 PGS002248
(PRSice_asthma)
PSS009557|
European Ancestry|
898 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 11 AUROC: 0.71 [0.61, 0.8] CAPE model
PPM012795 PGS002248
(PRSice_asthma)
PSS009558|
European Ancestry|
1,018 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 8 AUROC: 0.85 [0.77, 0.92] CAPP model
PPM012796 PGS002248
(PRSice_asthma)
PSS009557|
European Ancestry|
898 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 11 AUROC: 0.81 [0.72, 0.89] CAPP model

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009558 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last
[
  • 144 cases
  • , 874 controls
]
European MAAS
PSS009557 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last
[
  • 116 cases
  • , 782 controls
]
European MAAS