Polygenic Score (PGS) ID: PGS002256

Predicted Trait
Reported Trait Gestational diabetes mellitus in early pregnancy
Mapped Trait(s) gestational diabetes (EFO_0004593)
Released in PGS Catalog: Feb. 16, 2022
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Score Details

Score Construction
PGS Name GRS4_GDM
Development Method
Name Genome-wide significant variants
Parameters p < 0.05
Variants
Original Genome Build NR
Number of Variants 4
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000282
Citation (link to publication) Wu Q et al. Diabetol Metab Syndr (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
671 individuals (100%)
Score Development/Training
East Asian: 100%
291 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 332 cases
  • , 339 controls
]
,
0.0 % Male samples
 East Asian
(Chinese)		 NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 143 cases
  • , 148 controls
]
,
0.0 % Male samples
 East Asian
(Chinese)		 NR — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012834 PSS009573|
East Asian Ancestry|
985 individuals
 PGP000282 |
Wu Q et al. Diabetol Metab Syndr (2022)
 Reported Trait: Gestational diabetes mellitus in early pregnancy — AUROC: 0.62 [0.573, 0.667] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009573 — —
[
  • 191 cases
  • , 794 controls
]
,
0.0 % Male samples
 — East Asian
(Chinese)		 — NR —