Polygenic Score (PGS) ID: PGS002740

Predicted Trait
Reported Trait Pancreatic cancer
Mapped Trait(s) pancreatic carcinoma (EFO_0002618)
Released in PGS Catalog: Aug. 3, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS22_PC
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 22
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000347
Citation (link to publication) Yuan C et al. Ann Oncol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 88.1%
Not Reported: 10.2%
Multi-ancestry (excluding European): 0.9%
  • Not Reported
  • Hispanic or Latin American
  • African
  • Additional Asian Ancestries
Additional Diverse Ancestries: 0.5%
East Asian: 0.2%
68,762 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST000456
Europe PMC: 19648918
 3,576 individuals European NR
GWAS Catalog: GCST000574
Europe PMC: 20101243
 7,416 individuals European NR
GWAS Catalog: GCST000574
Europe PMC: 20101243
 369 individuals Other NR
GWAS Catalog: GCST000574
Europe PMC: 20101243
 126 individuals East Asian NR
GWAS Catalog: GCST005434
Europe PMC: 29422604
 21,536 individuals European 28 cohorts
  • AHS
  • ,ATBC
  • ,CLUEII
  • ,CPSII
  • ,DFCI-GCC
  • ,EPIC
  • ,HPFS
  • ,IARC
  • ,JHH
  • ,MAYO
  • ,MCCS
  • ,MDACCS
  • ,MEC
  • ,MSKCC
  • ,NHS
  • ,NYU-WHS
  • ,PANDoRA
  • ,PANKRAS-II
  • ,PHS
  • ,PLCO
  • ,QIMR
  • ,SELECT
  • ,SMWHS
  • ,UCSF
  • ,VITAL
  • ,WHI
  • ,WHS
  • ,Yale
GWAS Catalog: GCST002991
Europe PMC: 26098869
 7,046 individuals NR 9 cohorts
  • IARC
  • ,JHH
  • ,MAYO
  • ,MDACCS
  • ,MSKCC
  • ,QIMR
  • ,Toronto
  • ,UCSF
  • ,Yale
GWAS Catalog: GCST003758
Europe PMC: 27579533
 13,952 individuals European 28 cohorts
  • AHS
  • ,ATBC
  • ,CLUEII
  • ,CPSII
  • ,DFCI-GCC
  • ,EPIC
  • ,HPFS
  • ,Iowa-Mayo
  • ,JHH
  • ,MCCS
  • ,MDACCS
  • ,MEC
  • ,MSKCC
  • ,NHS
  • ,NYU-WHS
  • ,PACIFIC
  • ,PANDoRA
  • ,PANKRAS-II
  • ,PHS
  • ,PLCO
  • ,SELECT
  • ,SMWHS
  • ,Toronto
  • ,UCSF
  • ,VITAL
  • ,WHI
  • ,WHS
  • ,Yale
GWAS Catalog: GCST002553
Europe PMC: 25086665
 6,785 individuals European 16 cohorts
  • AHS
  • ,ATBC
  • ,CPSII
  • ,DFCI-GCC
  • ,EPIC
  • ,HPFS
  • ,MCCS
  • ,MEC
  • ,NHS
  • ,PANDoRA
  • ,PANKRAS-II
  • ,PHS
  • ,PLCO
  • ,SELECT
  • ,VITAL
  • ,WHI
GWAS Catalog: GCST002991
Europe PMC: 26098869
 7,320 individuals European 9 cohorts
  • IARC
  • ,JHH
  • ,MAYO
  • ,MDACCS
  • ,MSKCC
  • ,QIMR
  • ,Toronto
  • ,UCSF
  • ,Yale
GWAS Catalog: GCST002991
Europe PMC: 26098869
 636 individuals NR, Hispanic or Latin American, African unspecified, Asian unspecified 9 cohorts
  • IARC
  • ,JHH
  • ,MAYO
  • ,MDACCS
  • ,MSKCC
  • ,QIMR
  • ,Toronto
  • ,UCSF
  • ,Yale

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014844 PSS009913|
European Ancestry|
13,952 individuals
 PGP000347 |
Yuan C et al. Ann Oncol (2022)
 Reported Trait: Pancreatic cancer in those aged <= 60 years — — Odds ratio (OR, top vs bottom 10%): 6.91 [4.6, 10.4] — —
PPM014843 PSS009913|
European Ancestry|
13,952 individuals
 PGP000347 |
Yuan C et al. Ann Oncol (2022)
 Reported Trait: Pancreatic cancer in those aged >70 years — — Odds ratio (OR, top vs bottom 10%): 4.12 [3.08, 5.52] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009913 — —
[
  • 5,107 cases
  • , 8,845 controls
]
 — European — PANSCAN —