Polygenic Score (PGS) ID: PGS002749

Predicted Trait
Reported Trait Total knee replacement
Mapped Trait(s)
Released in PGS Catalog: Sept. 8, 2022
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Score Details

Score Construction
PGS Name PRS10_TKR
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 10
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000362
Citation (link to publication) Lacaze P et al. Arthritis Rheumatol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
252,041 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90034525
Europe PMC: 34450027
 252,041 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014939 PSS009936|
European Ancestry|
1,422 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Knee replacement OR: 1.13 [1.07, 1.2] — — Age, sex, body mass index, education, and index of relative socioeconomic advantage and disadvantage —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009936 — — 1,422 individuals — European — ASPREE —