PGS Publication: PGP000362

Publication Information (EuropePMC)
Title Genomic Risk Score for Advanced Osteoarthritis in Older Adults.
PubMed ID 35506208(Europe PMC)
doi 10.1002/art.42156
Publication Date July 23, 2022
Journal Arthritis Rheumatol
Author(s) Lacaze P, Wang Y, Polekhina G, Bakshi A, Riaz M, Owen A, Franks A, Abidi J, Tiller J, McNeil J, Cicuttini F.
Released in PGS Catalog: Sept. 8, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002749
(PRS10_TKR)
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Total knee replacement osteoarthritis, knee,
total knee arthroplasty		 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002749/ScoringFiles/PGS002749.txt.gz
PGS002750
(PRS37_THR)
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Total hip replacement total hip arthroplasty,
osteoarthritis, hip		 37
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002750/ScoringFiles/PGS002750.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014939 PGS002749
(PRS10_TKR)
 PSS009936|
European Ancestry|
1,422 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Knee replacement OR: 1.13 [1.07, 1.2] — — Age, sex, body mass index, education, and index of relative socioeconomic advantage and disadvantage —
PPM014940 PGS002750
(PRS37_THR)
 PSS009935|
European Ancestry|
1,257 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Hip replacement OR: 1.23 [1.16, 1.3] — — Age, sex, body mass index, education, and index of relative socioeconomic advantage and disadvantage —
PPM014941 PGS002750
(PRS37_THR)
 PSS009935|
European Ancestry|
1,257 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Hip replacement in men OR: 1.15 [1.06, 1.26] — — Age, body mass index, education, and index of relative socioeconomic advantage and disadvantage —
PPM014942 PGS002750
(PRS37_THR)
 PSS009935|
European Ancestry|
1,257 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Hip replacement in women OR: 1.3 [1.2, 1.4] — — Age, body mass index, education, and index of relative socioeconomic advantage and disadvantage —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009935 — — 1,257 individuals — European — ASPREE —
PSS009936 — — 1,422 individuals — European — ASPREE —