Polygenic Score (PGS) ID: PGS002807

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: Nov. 23, 2022
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Score Details

Score Construction
PGS Name PRSCS_SBP
Development Method
Name PRS-CS
Parameters Hapmap only variants with EUR as LD reference
Variants
Original Genome Build GRCh38
Number of Variants 1,084,157
Effect Weight Type posterior beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000384
Citation (link to publication) Parcha V et al. Circ Genom Precis Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 95.5%
Additional Asian Ancestries: 1.9%
African: 1.5%
East Asian: 0.6%
Greater Middle Eastern: 0.3%
Hispanic or Latin American: 0.2%
436,843 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • Hispanic or Latin American
  • Additional Diverse Ancestries
  • European
  • Additional Asian Ancestries
  • Greater Middle Eastern
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
6,408 individuals African unspecified UKB
950 individuals Hispanic or Latin American
(Admixed American)		 UKB
8,398 individuals Asian unspecified
(Central/South Asian)		 UKB
2,564 individuals East Asian UKB
417,001 individuals European UKB
1,522 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Middle Eastern)		 UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015554 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CVD events HR: 1.1 [1.03, 1.17] C-index: 0.58 — — —
PPM015562 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Hypertension OR: 1.28 [1.25, 1.3] — R²: 0.10982 — —
PPM015539 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Diastolic blood pressure β: 2.04 [1.89, 2.19] — R²: 0.12136 — —
PPM015549 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Diastolic blood pressure β: 1.07 [0.78, 1.36] — R²: 0.05373 — —
PPM015550 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Mean arterial pressure β: 1.71 [1.39, 2.04] — R²: 0.02742 — —
PPM015540 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Mean arterial pressure β: 2.82 [2.65, 3.0] — R²: 0.15868 — —
PPM015541 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Pulse pressure β: 2.35 [2.17, 2.53] — R²: 0.31658 — —
PPM015542 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Hypertension OR: 1.51 [1.46, 1.55] — R²: 0.21395 — —
PPM015543 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident ASCVD events HR: 1.05 [1.02, 1.08] C-index: 0.77 — — —
PPM015544 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CVD events HR: 1.06 [1.03, 1.09] C-index: 0.76 — — —
PPM015545 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHF events HR: 1.04 [1.0, 1.09] C-index: 0.83 — — —
PPM015547 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident stroke events HR: 1.04 [1.0, 1.09] C-index: 0.76 — — —
PPM015548 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Systolic blood pressure β: 2.33 [1.9, 2.75] — R²: 0.03615 — —
PPM015551 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Pulse pressure β: 1.94 [1.58, 2.3] — R²: 0.1185 — —
PPM015552 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Hypertension OR: 1.51 [1.39, 1.64] — R²: 0.04804 — —
PPM015553 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident ASCVD events HR: 1.13 [1.06, 1.19] C-index: 0.59 — — —
PPM015555 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHF events HR: 1.18 [1.06, 1.3] C-index: 0.65 — — —
PPM015556 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHD events HR: 1.1 [1.03, 1.17] C-index: 0.58 — — —
PPM015557 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident stroke events HR: 1.15 [0.96, 1.34] C-index: 0.69 — — —
PPM015558 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Systolic blood pressure β: 2.96 [2.79, 3.12] — R²: 0.16035 — —
PPM015559 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Diastolic blood pressure β: 1.43 [1.32, 1.54] — R²: 0.05359 — —
PPM015560 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Mean arterial pressure β: 1.94 [1.82, 2.06] — R²: 0.08936 — —
PPM015561 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Pulse pressure β: 1.53 [1.41, 1.64] — R²: 0.21397 — —
PPM015538 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Systolic blood pressure β: 4.39 [4.13, 4.65] — R²: 0.23786 — —
PPM015546 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHD events HR: 1.07 [1.04, 1.11] C-index: 0.77 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009980 — — 14,069 individuals — European
(White)		 — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009980 — — 6,186 individuals — African American or Afro-Caribbean
(Black)		 — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009980 — — 1,022 individuals — Hispanic or Latin American
(Hispanics)		 — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009980 — — 606 individuals — Asian unspecified — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009981 — — 936 individuals — African American or Afro-Caribbean
(Black)		 — NR —
PSS009981 — — 383 individuals — Hispanic or Latin American
(Hispanics)		 — NR —
PSS009981 — — 608 individuals — Other — NR —
PSS009981 — — 4,408 individuals — European — NR —
PSS009982 — — 1,453 individuals — Asian unspecified — NR —
PSS009982 — — 9,680 individuals — African American or Afro-Caribbean
(Black)		 — NR —
PSS009982 — — 314 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Middle Eastern)		 — NR —
PSS009982 — — 905 individuals — Other admixed ancestry more than 1 population NR —
PSS009982 — — 40 individuals — Native American — NR —
PSS009982 — — 31,706 individuals — European — NR —