PGS Publication: PGP000384

Publication Information (EuropePMC)
Title Association of a Multi-Ancestry Genome-Wide Blood Pressure Polygenic Risk Score with Adverse Cardiovascular Events.
PubMed ID 36334310(Europe PMC)
doi 10.1161/circgen.122.003946
Publication Date Nov. 5, 2022
Journal Circ Genom Precis Med
Author(s) Parcha V, Pampana A, Shetty NS, Irvin MR, Natarajan P, Lin HJ, Guo X, Rich SS, Rotter JI, Li P, Oparil S, Arora G, Arora P.
Released in PGS Catalog: Nov. 23, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002807
(PRSCS_SBP)
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Systolic blood pressure systolic blood pressure 1,084,157
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002807/ScoringFiles/PGS002807.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015554 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CVD events HR: 1.1 [1.03, 1.17] C-index: 0.58 — — —
PPM015562 PGS002807
(PRSCS_SBP)
 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Hypertension OR: 1.28 [1.25, 1.3] — R²: 0.10982 — —
PPM015539 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Diastolic blood pressure β: 2.04 [1.89, 2.19] — R²: 0.12136 — —
PPM015549 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Diastolic blood pressure β: 1.07 [0.78, 1.36] — R²: 0.05373 — —
PPM015550 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Mean arterial pressure β: 1.71 [1.39, 2.04] — R²: 0.02742 — —
PPM015540 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Mean arterial pressure β: 2.82 [2.65, 3.0] — R²: 0.15868 — —
PPM015541 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Pulse pressure β: 2.35 [2.17, 2.53] — R²: 0.31658 — —
PPM015542 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Hypertension OR: 1.51 [1.46, 1.55] — R²: 0.21395 — —
PPM015543 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident ASCVD events HR: 1.05 [1.02, 1.08] C-index: 0.77 — — —
PPM015544 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CVD events HR: 1.06 [1.03, 1.09] C-index: 0.76 — — —
PPM015545 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHF events HR: 1.04 [1.0, 1.09] C-index: 0.83 — — —
PPM015547 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident stroke events HR: 1.04 [1.0, 1.09] C-index: 0.76 — — —
PPM015548 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Systolic blood pressure β: 2.33 [1.9, 2.75] — R²: 0.03615 — —
PPM015551 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Pulse pressure β: 1.94 [1.58, 2.3] — R²: 0.1185 — —
PPM015552 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Hypertension OR: 1.51 [1.39, 1.64] — R²: 0.04804 — —
PPM015553 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident ASCVD events HR: 1.13 [1.06, 1.19] C-index: 0.59 — — —
PPM015555 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHF events HR: 1.18 [1.06, 1.3] C-index: 0.65 — — —
PPM015556 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHD events HR: 1.1 [1.03, 1.17] C-index: 0.58 — — —
PPM015557 PGS002807
(PRSCS_SBP)
 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident stroke events HR: 1.15 [0.96, 1.34] C-index: 0.69 — — —
PPM015558 PGS002807
(PRSCS_SBP)
 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Systolic blood pressure β: 2.96 [2.79, 3.12] — R²: 0.16035 — —
PPM015559 PGS002807
(PRSCS_SBP)
 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Diastolic blood pressure β: 1.43 [1.32, 1.54] — R²: 0.05359 — —
PPM015560 PGS002807
(PRSCS_SBP)
 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Mean arterial pressure β: 1.94 [1.82, 2.06] — R²: 0.08936 — —
PPM015561 PGS002807
(PRSCS_SBP)
 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Pulse pressure β: 1.53 [1.41, 1.64] — R²: 0.21397 — —
PPM015538 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Systolic blood pressure β: 4.39 [4.13, 4.65] — R²: 0.23786 — —
PPM015546 PGS002807
(PRSCS_SBP)
 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
 PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
 Reported Trait: Incident CHD events HR: 1.07 [1.04, 1.11] C-index: 0.77 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009980 — — 14,069 individuals — European
(White)		 — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009980 — — 6,186 individuals — African American or Afro-Caribbean
(Black)		 — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009980 — — 1,022 individuals — Hispanic or Latin American
(Hispanics)		 — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009980 — — 606 individuals — Asian unspecified — 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
 —
PSS009981 — — 936 individuals — African American or Afro-Caribbean
(Black)		 — NR —
PSS009981 — — 383 individuals — Hispanic or Latin American
(Hispanics)		 — NR —
PSS009981 — — 608 individuals — Other — NR —
PSS009981 — — 4,408 individuals — European — NR —
PSS009982 — — 1,453 individuals — Asian unspecified — NR —
PSS009982 — — 9,680 individuals — African American or Afro-Caribbean
(Black)		 — NR —
PSS009982 — — 314 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Middle Eastern)		 — NR —
PSS009982 — — 905 individuals — Other admixed ancestry more than 1 population NR —
PSS009982 — — 40 individuals — Native American — NR —
PSS009982 — — 31,706 individuals — European — NR —