Polygenic Score (PGS) ID: PGS002807

Predicted Trait
Reported Trait Systolic Blood Pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: Nov. 23, 2022
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Score Details

Score Construction
PGS Name PRSCS_SBP
Development Method
Name PRS-CS
Parameters Hapmap only variants with EUR as LD reference
Variants
Original Genome Build GRCh38
Number of Variants 1,084,157
Effect Weight Type posterior beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000384
Citation (link to publication) Parcha V et al. Circ Genom Precis Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 95.5%
Additional Asian Ancestries: 1.9%
African: 1.5%
East Asian: 0.6%
Greater Middle Eastern: 0.3%
Hispanic or Latin American: 0.2%
436,843 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • Additional Diverse Ancestries
  • Additional Asian Ancestries
  • Greater Middle Eastern
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
6,408 individuals African unspecified UKB
950 individuals Hispanic or Latin American
(Admixed American)
UKB
8,398 individuals Asian unspecified
(Central/South Asian)
UKB
2,564 individuals East Asian UKB
417,001 individuals European UKB
1,522 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Middle Eastern)
UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015554 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident CVD events HR: 1.1 [1.03, 1.17] C-index: 0.58
PPM015562 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Hypertension OR: 1.28 [1.25, 1.3] : 0.10982
PPM015539 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Diastolic blood pressure β: 2.04 [1.89, 2.19] : 0.12136
PPM015540 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Mean arterial pressure β: 2.82 [2.65, 3.0] : 0.15868
PPM015541 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Pulse pressure β: 2.35 [2.17, 2.53] : 0.31658
PPM015542 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Hypertension OR: 1.51 [1.46, 1.55] : 0.21395
PPM015543 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident ASCVD events HR: 1.05 [1.02, 1.08] C-index: 0.77
PPM015544 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident CVD events HR: 1.06 [1.03, 1.09] C-index: 0.76
PPM015545 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident CHF events HR: 1.04 [1.0, 1.09] C-index: 0.83
PPM015547 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident stroke events HR: 1.04 [1.0, 1.09] C-index: 0.76
PPM015548 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Systolic blood pressure β: 2.33 [1.9, 2.75] : 0.03615
PPM015549 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Diastolic blood pressure β: 1.07 [0.78, 1.36] : 0.05373
PPM015550 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Mean arterial pressure β: 1.71 [1.39, 2.04] : 0.02742
PPM015551 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Pulse pressure β: 1.94 [1.58, 2.3] : 0.1185
PPM015552 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Hypertension OR: 1.51 [1.39, 1.64] : 0.04804
PPM015553 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident ASCVD events HR: 1.13 [1.06, 1.19] C-index: 0.59
PPM015555 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident CHF events HR: 1.18 [1.06, 1.3] C-index: 0.65
PPM015556 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident CHD events HR: 1.1 [1.03, 1.17] C-index: 0.58
PPM015557 PSS009981|
Multi-ancestry (including European)|
6,335 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident stroke events HR: 1.15 [0.96, 1.34] C-index: 0.69
PPM015558 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Systolic blood pressure β: 2.96 [2.79, 3.12] : 0.16035
PPM015559 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Diastolic blood pressure β: 1.43 [1.32, 1.54] : 0.05359
PPM015560 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Mean arterial pressure β: 1.94 [1.82, 2.06] : 0.08936
PPM015561 PSS009982|
Multi-ancestry (including European)|
44,098 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Pulse pressure β: 1.53 [1.41, 1.64] : 0.21397
PPM015538 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Systolic blood pressure β: 4.39 [4.13, 4.65] : 0.23786
PPM015546 PSS009980|
Multi-ancestry (including European)|
21,883 individuals
PGP000384 |
Parcha V et al. Circ Genom Precis Med (2022)
Reported Trait: Incident CHD events HR: 1.07 [1.04, 1.11] C-index: 0.77

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009980 14,069 individuals European
(White)
6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
PSS009980 6,186 individuals African American or Afro-Caribbean
(Black)
6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
PSS009980 1,022 individuals Hispanic or Latin American
(Hispanics)
6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
PSS009980 606 individuals Asian unspecified 6 cohorts
  • ARIC
  • ,CARDIA
  • ,CHS
  • ,FHS
  • ,JHS
  • ,MESA
PSS009981 936 individuals African American or Afro-Caribbean
(Black)
NR
PSS009981 383 individuals Hispanic or Latin American
(Hispanics)
NR
PSS009981 608 individuals Other NR
PSS009981 4,408 individuals European NR
PSS009982 1,453 individuals Asian unspecified NR
PSS009982 9,680 individuals African American or Afro-Caribbean
(Black)
NR
PSS009982 314 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Middle Eastern)
NR
PSS009982 905 individuals Other admixed ancestry more than 1 population NR
PSS009982 40 individuals Native American NR
PSS009982 31,706 individuals European NR