Predicted Trait | |
Reported Trait | Type 2 diabetes (T2D) |
Mapped Trait(s) | type 2 diabetes mellitus (MONDO_0005148) |
Additional Trait Information | T2D; Binary |
Score Construction | |
PGS Name | ExPRSweb_T2D_30054458-GCST006867_PRSCS_UKB_20211120 |
Development Method | |
Name | PRS-CS |
Parameters | PRS-CS (auto) |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 945,921 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000393 |
Citation (link to publication) | Ma Y et al. Am J Hum Genet (2022) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST006867 Europe PMC: 30054458 |
[
|
European | NR |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | [
|
European | UKB | Field ID: 2443; Binary | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM016014 | PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 3.193 [3.12, 3.268] β: 1.16 (0.0118) |
AUROC: 0.786 [0.782, 0.791] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
PPM022819 | PSS012080| Greater Middle Eastern Ancestry| 4,534 individuals |
PGP000753 | Aliyu U et al. Diabetes Obes Metab (2025) |Ext. |
Reported Trait: Prediabetes | OR: 1.193 [1.114, 1.278] | AUROC: 0.646 [0.63, 0.662] | R²: 0.083 | sex, baseline age, BMI, PCs1-10 | — |
PPM022889 | PSS012081| Greater Middle Eastern Ancestry| 2,143 individuals |
PGP000753 | Aliyu U et al. Diabetes Obes Metab (2025) |Ext. |
Reported Trait: Incident T2D in prediabetics | HR: 1.64 [1.397, 1.925] | AUROC: 0.775 [0.742, 0.808] | — | sex, baseline age, BMI, PCs1-10 | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS012080 | age-matched cohort | — | [
|
— | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |
PSS012081 | — | Median = 6.0 years | [ ,
54.22 % Male samples |
— | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |
PSS010036 | Field ID: 2443; Binary | — | [
|
— | European | — | UKB | — |