Polygenic Score (PGS) ID: PGS003334

Predicted Trait
Reported Trait Dementia
Mapped Trait(s) dementia (MONDO_0001627)
Released in PGS Catalog: Dec. 6, 2022
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Score Details

Score Construction
PGS Name PRS_dementia
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08, r2>0.2
Variants
Original Genome Build NR
Number of Variants 27
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000402
Citation (link to publication) Chen Y et al. Arch Gerontol Geriatr (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
63,926 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007511
Europe PMC: 30820047
 63,926 individuals European ADGC, CHARGE, EADI, GERAD, PERADES

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016153 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident Alzheimer’s Disease — — Hazard ratio (HR, high vs low tertile): 1.75 [1.58, 1.93] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016154 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident vascular dementia — — Hazard ratio (HR, high vs low tertile): 1.55 [1.32, 1.82] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016155 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident dementia without cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 1.6 [1.48, 1.73] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016156 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident Alzheimer’s Disease without cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 1.84 [1.64, 2.07] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016152 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident dementia — — Hazard ratio (HR, high vs low tertile): 1.5 [1.41, 1.6] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016157 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident vascular dementia without cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 1.63 [1.31, 2.03] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016158 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident dementia with cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 2.62 [2.36, 2.91] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016159 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident Alzheimer’s Disease with cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 2.38 [2.02, 2.81] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016160 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident vascular dementia with cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 4.45 [3.47, 5.71] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010051 Adults aged 37-73 free of dementia at baseline. International Classification of Diseases (ICD-10) codes was used to define all-cause dementia (ICD-10 codes: F00, F01, F02, F03, F05.1, G30, G31.1, G31.8), Alzheimer’s dementia (AD) (ICD-10 codes: F00, G30), and vascular dementia (VaD) (ICD-10 codes: F01). —
[
  • 5,750 cases
  • , 198,896 controls
]
,
46.9 % Male samples
 Mean = 64.1 years European — UKB 5,750 (2.8%) all-cause dementia, 2,432 (1.2%) AD, and 936 (0.5%) VaD