PGS Publication: PGP000402

Publication Information (EuropePMC)
Title Cardiometabolic diseases, polygenic risk score, APOE genotype, and risk of incident dementia: A population-based prospective cohort study.
PubMed ID 36347157(Europe PMC)
doi 10.1016/j.archger.2022.104853
Publication Date Oct. 31, 2022
Journal Arch Gerontol Geriatr
Author(s) Chen Y, Zhang Y, Li S, Zhou L, Li H, Li D, Wang Y, Yang H.
Released in PGS Catalog: Dec. 6, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS003334
(PRS_dementia)
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Dementia dementia 27
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003334/ScoringFiles/PGS003334.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016153 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident Alzheimer’s Disease — — Hazard ratio (HR, high vs low tertile): 1.75 [1.58, 1.93] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016154 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident vascular dementia — — Hazard ratio (HR, high vs low tertile): 1.55 [1.32, 1.82] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016155 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident dementia without cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 1.6 [1.48, 1.73] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016156 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident Alzheimer’s Disease without cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 1.84 [1.64, 2.07] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016152 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident dementia — — Hazard ratio (HR, high vs low tertile): 1.5 [1.41, 1.6] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016157 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident vascular dementia without cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 1.63 [1.31, 2.03] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016158 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident dementia with cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 2.62 [2.36, 2.91] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016159 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident Alzheimer’s Disease with cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 2.38 [2.02, 2.81] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —
PPM016160 PGS003334
(PRS_dementia)
 PSS010051|
European Ancestry|
204,646 individuals
 PGP000402 |
Chen Y et al. Arch Gerontol Geriatr (2022)
 Reported Trait: Incident vascular dementia with cardiometabolic diseases — — Hazard ratio (HR, high vs low tertile): 4.45 [3.47, 5.71] Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010051 Adults aged 37-73 free of dementia at baseline. International Classification of Diseases (ICD-10) codes was used to define all-cause dementia (ICD-10 codes: F00, F01, F02, F03, F05.1, G30, G31.1, G31.8), Alzheimer’s dementia (AD) (ICD-10 codes: F00, G30), and vascular dementia (VaD) (ICD-10 codes: F01). —
[
  • 5,750 cases
  • , 198,896 controls
]
,
46.9 % Male samples
 Mean = 64.1 years European — UKB 5,750 (2.8%) all-cause dementia, 2,432 (1.2%) AD, and 936 (0.5%) VaD