Polygenic Score (PGS) ID: PGS003507

Predicted Trait
Reported Trait Testosterone (female only)
Mapped Trait(s) testosterone measurement (EFO_0004908)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-F_log_testosterone
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
158,529 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 158,529 individuals,
0.0 % Male samples
 European UKB — Mean = 56.2 years
Sd = 8.0 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017435 PSS010868|
European Ancestry|
8,475 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017519 PSS010784|
European Ancestry|
2,096 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017603 PSS010616|
European Ancestry|
2,874 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017687 PSS010532|
Greater Middle Eastern Ancestry|
372 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017771 PSS010196|
European Ancestry|
943 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017855 PSS010448|
South Asian Ancestry|
2,210 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017939 PSS010364|
East Asian Ancestry|
1,023 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018023 PSS010280|
African Ancestry|
1,233 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018107 PSS010700|
African Ancestry|
1,662 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Testosterone (female only) — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010784 — — 2,096 individuals,
0.0 % Male samples
 Mean = 54.1 years
Sd = 7.7 years		 European Polish UKB —
PSS010532 — — 372 individuals,
0.0 % Male samples
 Mean = 51.2 years
Sd = 7.7 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010280 — — 1,233 individuals,
0.0 % Male samples
 Mean = 52.1 years
Sd = 7.9 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010700 — — 1,662 individuals,
0.0 % Male samples
 Mean = 52.4 years
Sd = 8.0 years		 African unspecified Nigerian UKB —
PSS010448 — — 2,210 individuals,
0.0 % Male samples
 Mean = 52.4 years
Sd = 8.1 years		 South Asian Indian UKB —
PSS010196 — — 943 individuals,
0.0 % Male samples
 Mean = 57.4 years
Sd = 7.2 years		 European Ashkenazi UKB —
PSS010868 — — 8,475 individuals,
0.0 % Male samples
 Mean = 56.2 years
Sd = 7.9 years		 European white British UKB —
PSS010616 — — 2,874 individuals,
0.0 % Male samples
 Mean = 53.8 years
Sd = 8.3 years		 European Italian UKB —
PSS010364 — — 1,023 individuals,
0.0 % Male samples
 Mean = 52.1 years
Sd = 7.5 years		 East Asian Chinese UKB —