Predicted Trait | |
Reported Trait | Type 2 diabetes (T2D) |
Mapped Trait(s) | type 2 diabetes mellitus (MONDO_0005148) |
Score Construction | |
PGS Name | GenoBoost_type_2_diabetes_3 |
Development Method | |
Name | GenoBoost |
Parameters | lr=0.05, #snv=8000, model=Additive GenoBoost |
Variants | |
Original Genome Build | hg19 |
Number of Variants | 8,000 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000546 |
Citation (link to publication) | Ohta R et al. Nat Commun (2024) |
Ancestry Distribution | |
Score Development/Training | European: 100% 269,710 individuals (100%) |
PGS Evaluation | Greater Middle Eastern: 66.7% European: 33.3% 3 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | [ ,
46.4 % Male samples |
European (White British) |
UKB | — | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM020381 | PSS011343| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.70228 | Covariate-adjusted pseudo-R2: 0.03838 AUPRC: 0.70228 |
age, sex, PC1-10 | — |
PPM022861 | PSS012080| Greater Middle Eastern Ancestry| 4,534 individuals |
PGP000753 | Aliyu U et al. Diabetes Obes Metab (2025) |Ext. |
Reported Trait: Prediabetes | OR: 1.209 [1.134, 1.289] | AUROC: 0.65 [0.634, 0.666] | R²: 0.085 | sex, baseline age, BMI, PCs1-10 | — |
PPM022901 | PSS012081| Greater Middle Eastern Ancestry| 2,143 individuals |
PGP000753 | Aliyu U et al. Diabetes Obes Metab (2025) |Ext. |
Reported Trait: Incident T2D in prediabetics | HR: 1.525 [1.314, 1.77] | AUROC: 0.763 [0.73, 0.796] | — | sex, baseline age, BMI, PCs1-10 | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011343 | — | — | [ ,
46.0 % Male samples |
— | European (White British) |
— | UKB | — |
PSS012080 | age-matched cohort | — | [
|
— | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |
PSS012081 | — | Median = 6.0 years | [ ,
54.22 % Male samples |
— | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |