Polygenic Score (PGS) ID: PGS004595

Predicted Trait
Reported Trait Coronary heart disease
Mapped Trait(s) coronary artery disorder (MONDO_0005010)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS_CHD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 164
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000575
Citation (link to publication) Oni-Orisan A et al. Clin Pharmacol Ther (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
773,268 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 75%
European: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90132302
Europe PMC: 35915156
 773,268 individuals European CARDIoGRAMplusC4D, MVP, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020745 PSS011389|
European Ancestry|
21,824 individuals
 PGP000575 |
Oni-Orisan A et al. Clin Pharmacol Ther (2022)
 Reported Trait: Myocardial infarction in non-statin users HR: 1.59 [1.42, 1.78] — — Age, sex, hypertension, diabetes, and cigarette smoking status —
PPM020746 PSS011389|
European Ancestry|
21,824 individuals
 PGP000575 |
Oni-Orisan A et al. Clin Pharmacol Ther (2022)
 Reported Trait: Major adverse cardiovascular event in non-statin users HR: 1.35 [1.25, 1.46] — — Age, sex, hypertension, diabetes, and cigarette smoking status —
PPM036567 PSS012313|
Hispanic or Latin American Ancestry|
133,207 individuals
 PGP000830 |
Liu T et al. Eur J Prev Cardiol (2026)
|Ext.		 Reported Trait: Coronary heart disease OR: 1.09 [1.06, 1.13] AUROC: 0.746 [0.739, 0.752] — age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes —
PPM036575 PSS012314|
Hispanic or Latin American Ancestry|
43,338 individuals
 PGP000830 |
Liu T et al. Eur J Prev Cardiol (2026)
|Ext.		 Reported Trait: Coronary heart disease OR: 1.12 [1.07, 1.16] AUROC: 0.72 [0.71, 0.73] — age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes —
PPM036583 PSS012315|
Hispanic or Latin American Ancestry|
89,869 individuals
 PGP000830 |
Liu T et al. Eur J Prev Cardiol (2026)
|Ext.		 Reported Trait: Coronary heart disease OR: 1.08 [1.03, 1.12] AUROC: 0.746 [0.738, 0.755] — age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012315 — — 89,869 individuals,
0.0 % Male samples
 Mean = 50.8 years
Sd = 11.7 years		 Hispanic or Latin American
(Mexican)		 — MCPS —
PSS011389 — Median = 8.2 years 21,824 individuals,
43.4 % Male samples
 Median = 63.1 years European — GERA —
PSS012313 — Median = 20.3 years
Range = [19.4, 21.5] years
[
  • 5,163 cases
  • , 128,044 controls
]
,
33.0 % Male samples
 Mean = 51.2 years
Sd = 11.8 years		 Hispanic or Latin American
(Mexican)		 — MCPS —
PSS012314 — — 43,338 individuals,
100.0 % Male samples
 Mean = 52.0 years
Sd = 12.1 years		 Hispanic or Latin American
(Mexican)		 — MCPS —