| Publication Information (EuropePMC) | |
| Title | Polygenic prediction of coronary heart disease among 130 000 Mexican adults. |
| PubMed ID | 41231729(Europe PMC) |
| doi | 10.1093/eurjpc/zwaf728 |
| Publication Date | Feb. 1, 2026 |
| Journal | Eur J Prev Cardiol |
| Author(s) | Liu T, Berumen J, Torres J, Alegre-Díaz J, Baca P, González-Carballo C, Ramirez-Reyes R, Rivas F, Aguilar-Ramirez D, Bragg F, Herrington W, Hill M, Trichia E, Vergara-Lope A, Wade R, Collins R, Kuri-Morales P, Emberson JR, Tapia-Conyer R, Gnatiuc Friedrichs L. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000011 (GRS50) |
PGP000004 | Tada H et al. Eur Heart J (2015) |
Coronary artery disease | coronary artery disorder | 50 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz |
| PGS003725 (GPS_Mult) |
PGP000466 | Patel AP et al. Nat Med (2023) |
Coronary artery disease | coronary artery disorder | 1,296,172 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003725/ScoringFiles/PGS003725.txt.gz | |
| PGS000013 (GPS_CAD) |
PGP000006 | Khera AV et al. Nat Genet (2018) |
Coronary artery disease | coronary artery disorder | 6,630,150 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz | |
| PGS000337 (MetaPRS_CAD) |
PGP000104 | Koyama S et al. Nat Genet (2020) |
Coronary artery disease | coronary artery disorder | 75,028 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000337/ScoringFiles/PGS000337.txt.gz |
| PGS000018 (metaGRS_CAD) |
PGP000007 | Inouye M et al. J Am Coll Cardiol (2018) |
Coronary artery disease | coronary artery disorder | 1,745,179 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz | |
| PGS004595 (PRS_CHD) |
PGP000575 | Oni-Orisan A et al. Clin Pharmacol Ther (2022) |
Coronary heart disease | coronary artery disorder | 164 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004595/ScoringFiles/PGS004595.txt.gz |
| PGS001780 (CHD_PRSCS) |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Coronary heart disease | coronary artery disorder | 1,090,048 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001780/ScoringFiles/PGS001780.txt.gz |
| PGS003446 (TEM_CAD_PRS) |
PGP000446 | Tcheandjieu C et al. Nat Med (2022) |
Coronary artery disease | coronary artery disorder | 538,084 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003446/ScoringFiles/PGS003446.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM036566 | PGS000011 (GRS50) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.05 [1.03, 1.08] | AUROC: 0.745 [0.739, 0.752] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036567 | PGS004595 (PRS_CHD) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.09 [1.06, 1.13] | AUROC: 0.746 [0.739, 0.752] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036568 | PGS000337 (MetaPRS_CAD) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.2 [1.17, 1.23] | AUROC: 0.748 [0.742, 0.754] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036569 | PGS003446 (TEM_CAD_PRS) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.16 [1.12, 1.2] | AUROC: 0.746 [0.74, 0.753] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036570 | PGS001780 (CHD_PRSCS) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.2 [1.16, 1.23] | AUROC: 0.748 [0.741, 0.754] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036571 | PGS003725 (GPS_Mult) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.24 [1.2, 1.28] | AUROC: 0.749 [0.743, 0.755] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036574 | PGS000011 (GRS50) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.05 [1.01, 1.1] | AUROC: 0.719 [0.709, 0.729] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036575 | PGS004595 (PRS_CHD) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.12 [1.07, 1.16] | AUROC: 0.72 [0.71, 0.73] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036576 | PGS000337 (MetaPRS_CAD) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.27 [1.22, 1.33] | AUROC: 0.726 [0.716, 0.736] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036577 | PGS003446 (TEM_CAD_PRS) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.28 [1.21, 1.34] | AUROC: 0.724 [0.714, 0.734] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036578 | PGS001780 (CHD_PRSCS) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.26 [1.21, 1.32] | AUROC: 0.725 [0.715, 0.735] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036579 | PGS003725 (GPS_Mult) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.33 [1.27, 1.39] | AUROC: 0.729 [0.719, 0.738] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036582 | PGS000011 (GRS50) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.05 [1.01, 1.09] | AUROC: 0.746 [0.737, 0.755] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036583 | PGS004595 (PRS_CHD) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.08 [1.03, 1.12] | AUROC: 0.746 [0.738, 0.755] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036584 | PGS000337 (MetaPRS_CAD) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.14 [1.1, 1.19] | AUROC: 0.747 [0.738, 0.756] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036585 | PGS003446 (TEM_CAD_PRS) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.07 [1.02, 1.12] | AUROC: 0.746 [0.737, 0.754] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036586 | PGS001780 (CHD_PRSCS) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.15 [1.1, 1.19] | AUROC: 0.747 [0.738, 0.756] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036587 | PGS003725 (GPS_Mult) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.17 [1.13, 1.22] | AUROC: 0.747 [0.739, 0.756] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036572 | PGS000018 (metaGRS_CAD) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.19 [1.15, 1.23] | AUROC: 0.747 [0.741, 0.753] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036573 | PGS000013 (GPS_CAD) |
PSS012313| Hispanic or Latin American Ancestry| 133,207 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.17 [1.14, 1.2] | AUROC: 0.747 [0.741, 0.754] C-index: 0.749 [0.743, 0.755] |
— | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036580 | PGS000018 (metaGRS_CAD) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.27 [1.21, 1.34] | AUROC: 0.724 [0.714, 0.734] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036581 | PGS000013 (GPS_CAD) |
PSS012314| Hispanic or Latin American Ancestry| 43,338 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.24 [1.19, 1.29] | AUROC: 0.724 [0.715, 0.734] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036588 | PGS000018 (metaGRS_CAD) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.13 [1.08, 1.16] | AUROC: 0.747 [0.738, 0.755] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
| PPM036589 | PGS000013 (GPS_CAD) |
PSS012315| Hispanic or Latin American Ancestry| 89,869 individuals |
PGP000830 | Liu T et al. Eur J Prev Cardiol (2026) |Ext. |
Reported Trait: Coronary heart disease | OR: 1.12 [1.08, 1.16] | AUROC: 0.747 [0.738, 0.755] | — | age, sex, PC1-PC7, baseline waist-to-hip ratio, systolic and diastolic blood pressure, smoking status, level of education, and diabetes | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012315 | — | — | 89,869 individuals, 0.0 % Male samples |
Mean = 50.8 years Sd = 11.7 years |
Hispanic or Latin American (Mexican) |
— | MCPS | — |
| PSS012313 | — | Median = 20.3 years Range = [19.4, 21.5] years |
[ ,
33.0 % Male samples |
Mean = 51.2 years Sd = 11.8 years |
Hispanic or Latin American (Mexican) |
— | MCPS | — |
| PSS012314 | — | — | 43,338 individuals, 100.0 % Male samples |
Mean = 52.0 years Sd = 12.1 years |
Hispanic or Latin American (Mexican) |
— | MCPS | — |