Polygenic Score (PGS) ID: PGS005093

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disorder (MONDO_0005010)
Released in PGS Catalog: April 13, 2026
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name MetPRS
Development Method
Name LASSO
Parameters Using LASSO to ensemble 726 (Metabolon) and 141 (Nightingale) predicted score by OMICSPRED (Nature 616, 123-131 [2023]) with 5-folds cross validation
Variants
Original Genome Build GRCh37
Number of Variants 4,595
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000685
Citation (link to publication) Yang X et al. Nat Commun (2026)
Ancestry Distribution
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • Additional Asian Ancestries
  • African
  • Not Reported
391,536 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Additional Asian Ancestries
  • African
  • Not Reported
1 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 42,602 cases
  • , 348,934 controls
]
,
46.2 % Male samples
 European, Asian unspecified, African unspecified, NR
(White, Asian, Black, NR)		 UKB ICD-9: 410,4109,411,4119,412,4129,4140,4148,4149; ICD-10: I21,I21.0,I21.1,I21.2,I21.3,I21.4,I21.9,I22,I22.0,I22.1,I22.8,I22.9,I23,I23.0,I23.1,I23.2,I23.3,I23.4,I23.5,I23.6,I23.8,I24.0,I24.1,I24.8,I24.9,I25.0,I25.1,I25.2,I25.5,I25.6,I25.8,I25.9; OPCS4: K49,K49.1,K49.2,K49.3,K49.4,K49.8,K49.9,K75,K75.1,K75.2,K75.3,K75.4,K75.8,K75.9,K50.1,K50.2,K50.4,K40,K40.1,K40.2,K40.3,K40.4,K40.8,K40.9,K41,K41.1,K41.2,K41.3,K41.4,K41.8,K41.9,K42,K42.1,K42.2,K42.3,K42.4,K42.8,K42.9,K43,K43.1,K43.2,K43.3,K43.4,K43.8,K43.9,K44,K44.1,K44.2,K44.8,K44.9,K45.1,K45.2,K45.3,K45.4,K45.5,K45.6,K45.8,K45.9,K46,K46.1,K46.2,K46.3,K46.4,K46.5,K46.8,K46.9,K47.1 Mean = 56.5 years
Sd = 8.1 years		 Median = 12.3 years — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022184 PSS011833|
Multi-ancestry (including European)|
34,177 individuals
 PGP000685 |
Yang X et al. Nat Commun (2026)
 Reported Trait: coronary artery disease HR: 1.1 [1.09, 1.12]
OR: 1.14 [1.11, 1.17]		 — — age, sex, PC1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011833 — Median = 10.5 years
[
  • 6,421 cases
  • , 27,756 controls
]
,
34.0 % Male samples
 Mean = 62.6 years
Sd = 10.6 years		 European, Asian unspecified, African unspecified, NR
(White, Asian, Black, NR)		 — 10 cohorts
  • ARIC
  • ,CHS
  • ,COPDGene
  • ,DHS
  • ,FHS
  • ,GENOA
  • ,GeneSTAR
  • ,JHS
  • ,MESA
  • ,WHI
 —