PGS Publication: PGP000685

Publication Information (EuropePMC)
Title An integrated germline and somatic genomic model for coronary artery disease.
PubMed ID 41888514(Europe PMC)
doi 10.1038/s41467-026-70379-2
Publication Date March 26, 2026
Journal Nat Commun
Author(s) Yang X, Kim MS, Zhu X, Uddin MM, Nakao T, Cho SMJ, Koyama S, Xu T, Reeskamp LF, Zhang R, Liu Z, A Y, de Vries PS, Vasan RS, Boerwinkle E, Morrison AC, Psaty BM, Tracy RP, Heckbert SR, Cho MH, Yun JH, Palmer ND, Bowden DW, Murabito JM, Levy D, Heard-Costa NL, O'Connor GT, Becker LC, Kral BG, Yanek LR, Raffield LM, Hidalgo B, Rotter JI, Rich SS, Taylor KD, Post WS, Kooperberg C, Reiner AP, Mitchell BD, Kardia SLR, Smith JA, Peyser PA, Bielak LF, Yon DK, Won HH, Arnett DK, Smith AV, Gabriel SB, Ellinor PT, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Natarajan P, Wang M, Fahed AC.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005093
(MetPRS)
 PGP000685 |
Yang X et al. Nat Commun (2026)
 Coronary artery disease coronary artery disorder 4,595
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005093/ScoringFiles/PGS005093.txt.gz
PGS005094
(ProPRS)
 PGP000685 |
Yang X et al. Nat Commun (2026)
 Coronary artery disease coronary artery disorder 5,249
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005094/ScoringFiles/PGS005094.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022185 PGS005094
(ProPRS)
 PSS011833|
Multi-ancestry (including European)|
34,177 individuals
 PGP000685 |
Yang X et al. Nat Commun (2026)
 Reported Trait: coronary artery disease HR: 1.05 [1.03, 1.07]
OR: 1.07 [1.04, 1.1]		 — — age, sex, PC1-10 —
PPM022184 PGS005093
(MetPRS)
 PSS011833|
Multi-ancestry (including European)|
34,177 individuals
 PGP000685 |
Yang X et al. Nat Commun (2026)
 Reported Trait: coronary artery disease HR: 1.1 [1.09, 1.12]
OR: 1.14 [1.11, 1.17]		 — — age, sex, PC1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011833 — Median = 10.5 years
[
  • 6,421 cases
  • , 27,756 controls
]
,
34.0 % Male samples
 Mean = 62.6 years
Sd = 10.6 years		 European, Asian unspecified, African unspecified, NR
(White, Asian, Black, NR)		 — 10 cohorts
  • ARIC
  • ,CHS
  • ,COPDGene
  • ,DHS
  • ,FHS
  • ,GENOA
  • ,GeneSTAR
  • ,JHS
  • ,MESA
  • ,WHI
 —