Polygenic Score (PGS) ID: PGS005215

Predicted Trait
Reported Trait Addiction risk factors
Mapped Trait(s) substance-related disorder (MONDO_0002494)
Additional Trait Information A general addiction factor derived using genomic SEM on substance use disorders.
Released in PGS Catalog: May 20, 2025
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Score Details

Score Construction
PGS Name addiction_rf
Development Method
Name lassosum
Parameters pseudo-validation option
Variants
Original Genome Build hg19
Number of Variants 11,627
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000731
Citation (link to publication) Deng WQ et al. Alcohol Alcohol (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
647,703 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90274724
Europe PMC: 37250466
 647,703 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022596 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Alcohol use disorder (7-item problematic use index) β: 0.01 — adjusted R2 only by the PGS: -0.06 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012026 — — 1,534 individuals,
43.0 % Male samples
 Mean = 34.9 years
Sd = 14.2 years		 European — PATH —