PGS Publication: PGP000731

Publication Information (EuropePMC)
Title A high-resolution PheWAS approach to alcohol-related polygenic risk scores reveals mechanistic influences of alcohol reinforcing value and drinking motives.
PubMed ID 38261344(Europe PMC)
doi 10.1093/alcalc/agad093
Publication Date Jan. 1, 2024
Journal Alcohol Alcohol
Author(s) Deng WQ, Belisario K, Gray JC, Levitt EE, MacKillop J.
Released in PGS Catalog: May 20, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005213
(AUD)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Alcohol use disorder by DSM-V alcohol use disorder measurement 336,813
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005213/ScoringFiles/PGS005213.txt.gz
PGS005214
(PAU)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Problematic alcohol use alcohol use disorder measurement 453,914
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005214/ScoringFiles/PGS005214.txt.gz
PGS005215
(addiction_rf)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Addiction risk factors substance-related disorder 11,627
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005215/ScoringFiles/PGS005215.txt.gz
PGS005216
(drinks_per_week)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Drinks per week alcohol consumption quality 221,689
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005216/ScoringFiles/PGS005216.txt.gz
PGS005211
(AUDIT_C)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Alcohol use disorder (3-item consumption index) alcohol use disorder measurement 2,338,199
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005211/ScoringFiles/PGS005211.txt.gz
PGS005212
(AUDIT_P)
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Alcohol use disorder (7-item problematic use index) alcohol use disorder measurement 384,933
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005212/ScoringFiles/PGS005212.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022592 PGS005211
(AUDIT_C)
 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Alcohol use disorder (3-item consumption index) β: 0.12 — adjusted R2 only by the PGS: 1.35 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait
PPM022593 PGS005212
(AUDIT_P)
 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Alcohol use disorder (7-item problematic use index) β: 0.07 — adjusted R2 only by the PGS: 0.46 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait
PPM022594 PGS005213
(AUD)
 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Alcohol use disorder total <=8 β: 0.03 — adjusted R2 only by the PGS: 0.05 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait
PPM022595 PGS005214
(PAU)
 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Alcohol use disorder (7-item problematic use index) β: 0.06 — adjusted R2 only by the PGS: 0.35 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait
PPM022596 PGS005215
(addiction_rf)
 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Alcohol use disorder (7-item problematic use index) β: 0.01 — adjusted R2 only by the PGS: -0.06 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait
PPM022597 PGS005216
(drinks_per_week)
 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Drinks per week adjusted for body mass index β: 0.13 — adjusted R2 only by the PGS: 1.68 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012026 — — 1,534 individuals,
43.0 % Male samples
 Mean = 34.9 years
Sd = 14.2 years		 European — PATH —