Polygenic Score (PGS) ID: PGS005216

Predicted Trait
Reported Trait Drinks per week
Mapped Trait(s) alcohol consumption quality (OBA_1000840)
Additional Trait Information Number of standard alcohol drinks consumed per week.
Released in PGS Catalog: May 20, 2025
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Score Details

Score Construction
PGS Name drinks_per_week
Development Method
Name lassosum
Parameters The penalty parameters were selected based on maximizing the adjusted R2 for the respective alcohol phenotype while adjusting for the first 10 genetic PCs, age, sex, and an indicator for wave (indicating the version of genotyping array used for genetic sample processing).
Variants
Original Genome Build hg19
Number of Variants 221,689
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000731
Citation (link to publication) Deng WQ et al. Alcohol Alcohol (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
African: 100%
95,343 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90243981
Europe PMC: 36477530
 95,343 individuals African unspecified 23andMe, GERA, HRS, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022597 PSS012026|
European Ancestry|
1,534 individuals
 PGP000731 |
Deng WQ et al. Alcohol Alcohol (2024)
 Reported Trait: Drinks per week adjusted for body mass index β: 0.13 — adjusted R2 only by the PGS: 1.68 age, sex, first 10 genetic principal components beta coefficient for standardized PGS and standardized trait

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012026 — — 1,534 individuals,
43.0 % Male samples
 Mean = 34.9 years
Sd = 14.2 years		 European — PATH —