Polygenic Score (PGS) ID: PGS005230

Predicted Trait
Reported Trait Stroke
Mapped Trait(s) stroke (EFO_0000712)
Released in PGS Catalog: June 16, 2025
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS71_STROKE
Development Method
Name Genome-wide significant SNPs
Parameters r2<0.05, P<1E-05, MAF>0.05
Variants
Original Genome Build NR
Number of Variants 71
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000736
Citation (link to publication) Ma Y et al. Stroke (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
446,696 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006906
Europe PMC: 29531354
 446,696 individuals European 14 cohorts
  • CADISP
  • ,CHARGE
  • ,EPIC
  • ,Finland
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,MDC
  • ,METASTROKE
  • ,Other
  • ,SAHLSIS
  • ,SIFAP
  • ,SiGN
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022648 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Incident stroke HR: 1.09 [1.07, 1.11] — — age, sex, genotyping batch, and the first ten genetic principal components —
PPM022649 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Incident Ischemic stroke HR: 1.12 [1.09, 1.15] — — age, sex, genotyping batch, and the first ten genetic principal components —
PPM022652 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution PM10 exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.48 [1.33, 1.65] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —
PPM022653 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution NO2 exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.51 [1.35, 1.69] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —
PPM022654 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution NOx exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.39 [1.25, 1.55] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —
PPM022650 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Incident Hemorrhagic stroke HR: 1.05 [1.0, 1.1] — — age, sex, genotyping batch, and the first ten genetic principal components —
PPM022651 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution PM2.5 exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.45 [1.31, 1.61] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012047 — —
[
  • 11,334 cases
  • , 440,862 controls
]
,
45.5 % Male samples
 Mean = 56.48 years
Sd = 8.1 years		 European — UKB —