PGS Publication: PGP000736

Publication Information (EuropePMC)
Title Genetic Susceptibility Modifies Relationships Between Air Pollutants and Stroke Risk: A Large Cohort Study.
PubMed ID 38134266(Europe PMC)
doi 10.1161/strokeaha.123.044284
Publication Date Dec. 22, 2023
Journal Stroke
Author(s) Ma Y, Zhang J, Li D, Tang L, Li Y, Cui F, Wang J, Wen C, Yang J, Tian Y.
Released in PGS Catalog: June 16, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005230
(PRS71_STROKE)
 PGP000736 |
Ma Y et al. Stroke (2023)
 Stroke stroke 71
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005230/ScoringFiles/PGS005230.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022648 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Incident stroke HR: 1.09 [1.07, 1.11] — — age, sex, genotyping batch, and the first ten genetic principal components —
PPM022649 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Incident Ischemic stroke HR: 1.12 [1.09, 1.15] — — age, sex, genotyping batch, and the first ten genetic principal components —
PPM022652 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution PM10 exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.48 [1.33, 1.65] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —
PPM022653 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution NO2 exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.51 [1.35, 1.69] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —
PPM022654 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution NOx exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.39 [1.25, 1.55] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —
PPM022650 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Incident Hemorrhagic stroke HR: 1.05 [1.0, 1.1] — — age, sex, genotyping batch, and the first ten genetic principal components —
PPM022651 PGS005230
(PRS71_STROKE)
 PSS012047|
European Ancestry|
452,196 individuals
 PGP000736 |
Ma Y et al. Stroke (2023)
 Reported Trait: Stroke onset x air pollution PM2.5 exposure interaction — — Hazard ratio (HR, high PM2.5 and high PRS vs. low PM2.5 and low PRS): 1.45 [1.31, 1.61] sex, ethnicity, household income, educational background, alcohol consumption status, smoking status, healthy diet score, physical activity, body mass index, hypertension, hyperlipidemia, diabetes, asthma, chronic obstructive pulmonary disease, genotyping batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012047 — —
[
  • 11,334 cases
  • , 440,862 controls
]
,
45.5 % Male samples
 Mean = 56.48 years
Sd = 8.1 years		 European — UKB —